ADAM18
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 18 | Ensembl:ENSG00000168619 | HGNC:HGNC:196 | PA24513 | 8p11.22 |
GO terms in ADAM18
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0008237 | metallopeptidase activity |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0030154 | cell differentiation |
Gene expression in normal tissue: ADAM18
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM18
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD150 | RITA | 4 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD505 | Pevonedistat | 7 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM18
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