ADAM18


Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM ID
PHARMGKB IDPA24513
Map Location8p11.22

GO terms in ADAM18


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004222 metalloendopeptidase activity
MF TAS GO:0008237 metallopeptidase activity
CC TAS GO:0016020 membrane
CC IEA GO:0016021 integral component of membrane
BP IEA GO:0006508 proteolysis
BP IEA GO:0007275 multicellular organism development
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Gene expression in normal tissue: ADAM18

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined27Mitosis1Stilbenoid, diarylheptanoid and gingerol biosynthesis1ERK MAPK signaling1Apoptosis regulation1Ferroptosis1

Pathways in ADAM18


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD144 NSC95397 4
iGMDRD427 ABT737 4
iGMDRD670 ML 210 3
iGMDRD889 Compound 7d-cis 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAM18

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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