EPHA10
Summary: Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor A10 | MIM:611123 | Ensembl:ENSG00000183317 | HGNC:HGNC:19987 | PA134938798 | 1p34.3 |
GO terms in EPHA10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005003 | ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ND | GO:0008150 | biological_process |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: EPHA10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHA10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD427 | ABT737 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHA10
CLASSFICATION
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