EPHA10

Summary: Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameEPH receptor A10
OMIM IDMIM:611123
Ensembl IDEnsembl:ENSG00000183317
HGNC IDHGNC:HGNC:19987
PHARMGKB IDPA134938798
Map Location1p34.3

GO terms in EPHA10


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IBA GO:0004888 transmembrane signaling receptor activity
MF IEA GO:0005003 ephrin receptor activity
MF IBA GO:0005005 transmembrane-ephrin receptor activity
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Gene expression in normal tissue: EPHA10

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 13undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 16BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3

Gene-drug pathway distribution

undefined11Longevity regulating pathway1Cell cycle1Apoptosis regulation1

Pathways in EPHA10


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-3928663 EPHA-mediated growth cone collapse
reactome R-HSA-3928663 EPHA-mediated growth cone collapse
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD511 CHEMBL399379 2
iGMDRD886 Compound 1541A 3
iGMDRD60 Quinoclamine 3
iGMDRD351 GW843682X 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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