Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].

activin A receptor type 2BMIM:602730Ensembl:ENSG00000114739HGNC:HGNC:174PA244953p22.2

GO terms in ACVR2B

Term TypeEvidence TypeGO Term IDGO Des.
BPIGIGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001702gastrulation with mouth forming second
BPIEAGO:0001822kidney development
BPISSGO:0001974blood vessel remodeling
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006468protein phosphorylation
BPIDAGO:0007165signal transduction
BPTASGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007368determination of left/right symmetry
BPIBAGO:0007389pattern specification process
BPIEAGO:0007498mesoderm development
BPIEAGO:0007507heart development
BPIEAGO:0009749response to glucose
BPIEAGO:0009791post-embryonic development
BPIMPGO:0009952anterior/posterior pattern specification
BPIEAGO:0030073insulin secretion
BPIEAGO:0030324lung development
BPIMPGO:0030501positive regulation of bone mineralization
BPIDAGO:0030509BMP signaling pathway
BPIMPGO:0030509BMP signaling pathway
BPTASGO:0030509BMP signaling pathway
BPIEAGO:0031016pancreas development
BPIEAGO:0032147activation of protein kinase activity
BPIBAGO:0032924activin receptor signaling pathway
BPIMPGO:0032924activin receptor signaling pathway
BPIDAGO:0032927positive regulation of activin receptor signaling pathway
BPIEAGO:0035265organ growth
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPIEAGO:0048617embryonic foregut morphogenesis
BPIEAGO:0048705skeletal system morphogenesis
BPIEAGO:0060021roof of mouth development
BPISSGO:0060836lymphatic endothelial cell differentiation
BPISSGO:0060840artery development
BPISSGO:0060841venous blood vessel development
BPISSGO:0061298retina vasculature development in camera-type eye
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0032991protein-containing complex
CCIBAGO:0043235receptor complex
CCIPIGO:0043235receptor complex
CCIBAGO:0048179activin receptor complex
MFEXPGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005026transforming growth factor beta receptor activity, type II
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016362activin receptor activity, type II
MFIBAGO:0019838growth factor binding
MFIPIGO:0019838growth factor binding
MFIBAGO:0034713type I transforming growth factor beta receptor binding
MFIBAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0048185activin binding
MFIEAGO:0048185activin binding

Gene expression in normal tissue: ACVR2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACVR2B

DatabasePathway IDPathway Des.
reactomeR-HSA-1181150Signaling by NODAL
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1433617Regulation of signaling by NODAL
reactomeR-HSA-1502540Signaling by Activin
reactomeR-HSA-1502540Signaling by Activin
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-201451Signaling by BMP
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9006936Signaling by TGF-beta family members
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
humancycPWY66-11BMP Signalling Pathway
pidalk1pathwayALK1 signaling events
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD887Compound 23 citrate1
iGMDRD286Nsc 6328392
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACVR2B