ACVR2B
Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602730 Ensembl IDEnsembl:ENSG00000114739 HGNC IDHGNC:HGNC:174 PHARMGKB IDPA24495 Map Location3p22.2 | |||||
GO terms in ACVR2B
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IGI | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001702 | gastrulation with mouth forming second |
| BP | IEA | GO:0001822 | kidney development |
| BP | ISS | GO:0001946 | lymphangiogenesis |
| BP | ISS | GO:0001974 | blood vessel remodeling |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
Gene expression in normal tissue: ACVR2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACVR2B
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1433617 | Regulation of signaling by NODAL |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACVR2B
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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