ACVR2B
Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| activin A receptor type 2B | MIM:602730 | Ensembl:ENSG00000114739 | HGNC:HGNC:174 | PA24495 | 3p22.2 |
GO terms in ACVR2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IGI | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001702 | gastrulation with mouth forming second |
| BP | IEA | GO:0001822 | kidney development |
| BP | ISS | GO:0001946 | lymphangiogenesis |
| BP | ISS | GO:0001974 | blood vessel remodeling |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| BP | IBA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007368 | determination of left/right symmetry |
| BP | IBA | GO:0007389 | pattern specification process |
| BP | IEA | GO:0007498 | mesoderm development |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0009791 | post-embryonic development |
| BP | IMP | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0030073 | insulin secretion |
| BP | IEA | GO:0030324 | lung development |
| BP | IMP | GO:0030501 | positive regulation of bone mineralization |
| BP | IDA | GO:0030509 | BMP signaling pathway |
| BP | IMP | GO:0030509 | BMP signaling pathway |
| BP | TAS | GO:0030509 | BMP signaling pathway |
| BP | IEA | GO:0031016 | pancreas development |
| BP | IEA | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0032924 | activin receptor signaling pathway |
| BP | IMP | GO:0032924 | activin receptor signaling pathway |
| BP | IDA | GO:0032927 | positive regulation of activin receptor signaling pathway |
| BP | IEA | GO:0035265 | organ growth |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IMP | GO:0045669 | positive regulation of osteoblast differentiation |
| BP | IEA | GO:0048617 | embryonic foregut morphogenesis |
| BP | IEA | GO:0048705 | skeletal system morphogenesis |
| BP | IEA | GO:0060021 | roof of mouth development |
| BP | ISS | GO:0060836 | lymphatic endothelial cell differentiation |
| BP | ISS | GO:0060840 | artery development |
| BP | ISS | GO:0060841 | venous blood vessel development |
| BP | ISS | GO:0061298 | retina vasculature development in camera-type eye |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IPI | GO:0043235 | receptor complex |
| CC | IBA | GO:0048179 | activin receptor complex |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IBA | GO:0005024 | transforming growth factor beta-activated receptor activity |
| MF | IBA | GO:0005026 | transforming growth factor beta receptor activity, type II |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016362 | activin receptor activity, type II |
| MF | IBA | GO:0019838 | growth factor binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | IBA | GO:0034713 | type I transforming growth factor beta receptor binding |
| MF | IBA | GO:0046332 | SMAD binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0048185 | activin binding |
| MF | IEA | GO:0048185 | activin binding |
Gene expression in normal tissue: ACVR2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ACVR2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1433617 | Regulation of signaling by NODAL |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-201451 | Signaling by BMP |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| humancyc | PWY66-11 | BMP Signalling Pathway |
| pid | alk1pathway | ALK1 signaling events |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD150 | RITA | 10 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ACVR2B
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