GLYAT

Summary: The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameglycine-N-acyltransferase
OMIM IDMIM:607424
Ensembl IDEnsembl:ENSG00000149124
HGNC IDHGNC:HGNC:13734
PHARMGKB IDPA28748
Map Location11q12.1

GO terms in GLYAT


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006544 glycine metabolic process
BP ISS GO:0006544 glycine metabolic process
BP TAS GO:0006637 acyl-CoA metabolic process
BP TAS GO:0006805 xenobiotic metabolic process
BP IEA GO:0009636 response to toxic substance
BP ISS GO:0032787 monocarboxylic acid metabolic process
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Gene expression in normal tissue: GLYAT

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined26Longevity regulating pathway1Apoptosis regulation1Biosynthesis of secondary metabolites1Other, kinases1

Pathways in GLYAT


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-156580 Phase II - Conjugation of compounds
reactome R-HSA-156587 Amino Acid conjugation
reactome R-HSA-159424 Conjugation of carboxylic acids
reactome R-HSA-177128 Conjugation of salicylate with glycine
reactome R-HSA-177135 Conjugation of benzoate with glycine
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD506 Fedratinib 2
iGMDRD888 Compound 44 4
iGMDRD871 BRD6368 1
iGMDRD100 Zebularine 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLYAT

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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