GLYAT
Summary: The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glycine-N-acyltransferase | MIM:607424 | Ensembl:ENSG00000149124 | HGNC:HGNC:13734 | PA28748 | 11q12.1 |
GO terms in GLYAT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006544 | glycine metabolic process |
| BP | ISS | GO:0006544 | glycine metabolic process |
| BP | TAS | GO:0006637 | acyl-CoA metabolic process |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | ISS | GO:0032787 | monocarboxylic acid metabolic process |
| BP | IDA | GO:1901787 | benzoyl-CoA metabolic process |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0016746 | transferase activity, transferring acyl groups |
| MF | IDA | GO:0047961 | glycine N-acyltransferase activity |
| MF | IDA | GO:0047962 | glycine N-benzoyltransferase activity |
| MF | ISS | GO:0047962 | glycine N-benzoyltransferase activity |
| MF | TAS | GO:0047962 | glycine N-benzoyltransferase activity |
Gene expression in normal tissue: GLYAT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GLYAT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156587 | Amino Acid conjugation |
| reactome | R-HSA-159424 | Conjugation of carboxylic acids |
| reactome | R-HSA-177128 | Conjugation of salicylate with glycine |
| reactome | R-HSA-177135 | Conjugation of benzoate with glycine |
| reactome | R-HSA-211859 | Biological oxidations |
| kegg | hsa00360 | Phenylalanine metabolism - Homo sapiens (human) |
| wikipathways | WP521 | Amino acid conjugation of benzoic acid |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| smpdb | SMP00126 | Phenylacetate Metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD150 | RITA | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GLYAT
CLASSFICATION
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