IRAK1
Summary: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300283 Ensembl IDEnsembl:ENSG00000184216 HGNC IDHGNC:HGNC:6112 PHARMGKB IDPA29912 Map LocationXq28 | |||||
GO terms in IRAK1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IMP | GO:0001959 | regulation of cytokine-mediated signaling pathway |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | TAS | GO:0006468 | protein phosphorylation |
Gene expression in normal tissue: IRAK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRAK1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRAK1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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