FANCF


Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
FA complementation group FMIM:613897Ensembl:ENSG00000183161HGNC:HGNC:3587PA2800111p14.3

GO terms in FANCF


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIPIGO:0005515protein binding
CCTASGO:0005654nucleoplasm
CCIDAGO:0043240Fanconi anaemia nuclear complex
BPNDGO:0008150biological_process
BPTASGO:0036297interstrand cross-link repair

Gene expression in normal tissue: FANCF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FANCF


DatabasePathway IDPathway Des.
pidbard1pathwayBARD1 signaling events
pidfanconi_pathwayFanconi anemia pathway
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)
reactomeR-HSA-6783310Fanconi Anemia Pathway
reactomeR-HSA-73894DNA Repair
biocartaatrbrcapathwayrole of brca1 brca2 and atr in cancer susceptibility
biocartabard1pathwaybrca1 dependent ub ligase activity

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD103SN-383
iGMDRD77Itraconazole3
iGMDRD318PAC-13
iGMDRD434BMS-5369243
iGMDRD289Parthenolide1
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide3
iGMDRD366PI-1033
iGMDRD780PP-302
iGMDRD577BIX012942
iGMDRD329Merck603
iGMDRD872BRD71373
iGMDRD871BRD63683
iGMDRD42Vorinostat3
iGMDRD505Pevonedistat6
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib3
iGMDRD781Sirolimus4
iGMDRD150RITA3
iGMDRD116CD4373
iGMDRD237ABT-7513
iGMDRD351GW843682X3
iGMDRD446LY 21832403
iGMDRD435BI-25363
iGMDRD945ML2146
iGMDRD123Isoevodiamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FANCF

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