SOCS3
Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| suppressor of cytokine signaling 3 | MIM:604176 | Ensembl:ENSG00000184557 | HGNC:HGNC:19391 | PA134885765 | 17q25.3 |
GO terms in SOCS3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| BP | IEA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0007259 | JAK-STAT cascade |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0040008 | regulation of growth |
| BP | TAS | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IMP | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | IEA | GO:0045597 | positive regulation of cell differentiation |
| BP | IMP | GO:0046426 | negative regulation of JAK-STAT cascade |
| BP | IBA | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| BP | TAS | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway |
| BP | IEA | GO:0060670 | branching involved in labyrinthine layer morphogenesis |
| BP | IEA | GO:0060674 | placenta blood vessel development |
| BP | IEA | GO:0060707 | trophoblast giant cell differentiation |
| BP | IEA | GO:0060708 | spongiotrophoblast differentiation |
| BP | TAS | GO:0070102 | interleukin-6-mediated signaling pathway |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| MF | IEA | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity |
Gene expression in normal tissue: SOCS3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SOCS3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | epopathway | EPO signaling pathway |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2815 | Mammary gland development pathway - Involution (Stage 4 of 4) |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3826 | Signaling by PTK6 |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| reactome | R-HSA-1059683 | Interleukin-6 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6783589 | Interleukin-6 family signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-877312 | Regulation of IFNG signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849474 | PTK6 Activates STAT3 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939242 | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes |
| reactome | R-HSA-8951664 | Neddylation |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-912694 | Regulation of IFNA signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD71 | Sparfosic acid | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD329 | Merck60 | 8 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD150 | RITA | 5 |
| iGMDRD701 | NVP-AUY922 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SOCS3
CLASSFICATION
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