SCYL3
Summary: This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SCY1 like pseudokinase 3 | MIM:608192 | Ensembl:ENSG00000000457 | HGNC:HGNC:19285 | PA142670945 | 1q24.2 |
GO terms in SCYL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0016477 | cell migration |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0030027 | lamellipodium |
Gene expression in normal tissue: SCYL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCYL3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD150 | RITA | 6 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD255 | SB225002 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCYL3
CLASSFICATION
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