BCL2L1


Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BCL2 like 1MIM:600039Ensembl:ENSG00000171552HGNC:HGNC:992PA7620q11.21

GO terms in BCL2L1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIBAGO:0005741mitochondrial outer membrane
CCNASGO:0005741mitochondrial outer membrane
CCTASGO:0005741mitochondrial outer membrane
CCIEAGO:0005743mitochondrial inner membrane
CCIEAGO:0005759mitochondrial matrix
CCIEAGO:0005783endoplasmic reticulum
CCIDAGO:0005813centrosome
CCIEAGO:0005829cytosol
CCIEAGO:0016021integral component of membrane
CCIEAGO:0030054cell junction
CCIEAGO:0030672synaptic vesicle membrane
CCIEAGO:0031965nuclear membrane
CCIDAGO:0097136Bcl-2 family protein complex
BPIEAGO:0001541ovarian follicle development
BPIEAGO:0001701in utero embryonic development
BPIDAGO:0001836release of cytochrome c from mitochondria
BPIEAGO:0006897endocytosis
BPIMPGO:0007093mitotic cell cycle checkpoint
BPIEAGO:0007281germ cell development
BPIEAGO:0007283spermatogenesis
BPIEAGO:0008283cell proliferation
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0008584male gonad development
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPTASGO:0008637apoptotic mitochondrial changes
BPIEAGO:0009566fertilization
BPIDAGO:0019050suppression by virus of host apoptotic process
BPTASGO:0019221cytokine-mediated signaling pathway
BPIMPGO:0032465regulation of cytokinesis
BPIDAGO:0034097response to cytokine
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0046898response to cycloheximide
BPIDAGO:0046902regulation of mitochondrial membrane permeability
BPIEAGO:0051402neuron apoptotic process
BPIDAGO:0051881regulation of mitochondrial membrane potential
BPIEAGO:0060154cellular process regulating host cell cycle in response to virus
BPIEAGO:0070584mitochondrion morphogenesis
BPIEAGO:0071230cellular response to amino acid stimulus
BPIEAGO:0071312cellular response to alkaloid
BPIEAGO:0071480cellular response to gamma radiation
BPIEAGO:0071839apoptotic process in bone marrow
BPICGO:0090201negative regulation of release of cytochrome c from mitochondria
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:0097284hepatocyte apoptotic process
BPIDAGO:1900118negative regulation of execution phase of apoptosis
BPIDAGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIDAGO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
BPIDAGO:1903077negative regulation of protein localization to plasma membrane
BPTASGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
BPIBAGO:2001243negative regulation of intrinsic apoptotic signaling pathway
BPIDAGO:2001243negative regulation of intrinsic apoptotic signaling pathway
BPTASGO:2001244positive regulation of intrinsic apoptotic signaling pathway
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0042803protein homodimerization activity
MFIBAGO:0046982protein heterodimerization activity
MFIPIGO:0051434BH3 domain binding

Gene expression in normal tissue: BCL2L1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL2L1


DatabasePathway IDPathway Des.
pidatf2_pathwayATF-2 transcription factor network
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidcd40_pathwayCD40/CD40L signaling
pidepopathwayEPO signaling pathway
piderbb1_downstream_pathwayErbB1 downstream signaling
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidp53downstreampathwayDirect p53 effectors
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
pharmgkbPA165374494Busulfan Pathway, Pharmacodynamics
netpathPathway_TNFalphaTNFalpha
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP254Apoptosis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP3672LncRNA-mediated mechanisms of therapeutic resistance
wikipathwaysWP3872Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-111453BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-844455The NLRP1 inflammasome
biocartaaifpathwayopposing roles of aif in apoptosis and cell survival
biocartabadpathwayregulation of bad phosphorylation
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
biocartaraspathwayras signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD698Neratinib1
iGMDRD435BI-25361
iGMDRD116CD4372
iGMDRD150RITA1
iGMDRD871BRD63684
iGMDRD414MST-3122
iGMDRD286Nsc 6328392
iGMDRD872BRD71371
iGMDRD366PI-1033
iGMDRD505Pevonedistat2
iGMDRD42Vorinostat3
iGMDRD434BMS-5369244
iGMDRD77Itraconazole3
iGMDRD267Oligomycin A1
iGMDRD61Kinetin riboside1
iGMDRD297Austocystin D2
iGMDRD679Bistramide A3
iGMDRD634SCHEMBL26080412
iGMDRD126Tipifarnib5
iGMDRD387CHIR-990211
iGMDRD144NSC953972
iGMDRD781Sirolimus1
iGMDRD188Piperlongumine3
iGMDRD506Fedratinib5
iGMDRD577BIX012943
iGMDRD398Sepantronium1
iGMDRD780PP-301
iGMDRD60Quinoclamine3
iGMDRD23Gossypol3
iGMDRD524ISX-95
iGMDRD255SB2250022
iGMDRD568SCHEMBL150055121
iGMDRD782DC-45-A22
iGMDRD885Compound 1105

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL2L1

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