BCL2L1
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameBCL2 like 1 OMIM IDMIM:600039 Ensembl IDEnsembl:ENSG00000171552 HGNC IDHGNC:HGNC:992 PHARMGKB IDPA76 Map Location20q11.21 | |||||
GO terms in BCL2L1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005741 | mitochondrial outer membrane |
| CC | NAS | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IEA | GO:0005743 | mitochondrial inner membrane |
Gene expression in normal tissue: BCL2L1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL2L1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | epopathway | EPO signaling pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL2L1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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