FOXP1


Summary: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
forkhead box P1MIM:605515Ensembl:ENSG00000114861HGNC:HGNC:3823PA282413p13

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in FOXP1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0002903negative regulation of B cell apoptotic process
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIMPGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0030316osteoclast differentiation
BPIDAGO:0032496response to lipopolysaccharide
BPIDAGO:0032680regulation of tumor necrosis factor production
BPTASGO:0035019somatic stem cell population maintenance
BPIDAGO:0035926chemokine (C-C motif) ligand 2 secretion
BPIDAGO:0036035osteoclast development
BPIDAGO:0042116macrophage activation
BPIDAGO:0042117monocyte activation
BPIMPGO:0042118endothelial cell activation
BPIDAGO:0045655regulation of monocyte differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0048661positive regulation of smooth muscle cell proliferation
BPIDAGO:0050706regulation of interleukin-1 beta secretion
BPIDAGO:0050727regulation of inflammatory response
BPIDAGO:0060766negative regulation of androgen receptor signaling pathway
BPISSGO:0061470T follicular helper cell differentiation
BPISSGO:0072619interleukin-21 secretion
BPIDAGO:1900424regulation of defense response to bacterium
BPIDAGO:1901256regulation of macrophage colony-stimulating factor production
BPIMPGO:1901509regulation of endothelial tube morphogenesis
BPIDAGO:2001182regulation of interleukin-12 secretion
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0043565sequence-specific DNA binding
MFIMPGO:0043621protein self-association
MFIEAGO:0046872metal ion binding
MFIDAGO:0050681androgen receptor binding

Gene expression in normal tissue: FOXP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXP1


DatabasePathway IDPathway Des.
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-452723Transcriptional regulation of pluripotent stem cells

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD105Triptolide5
iGMDRD705Nakiterpiosin3
iGMDRD103SN-388
iGMDRD505Pevonedistat6
iGMDRD506Fedratinib3
iGMDRD888Compound 441
iGMDRD871BRD63683
iGMDRD872BRD71373
iGMDRD200STF622471
iGMDRD701NVP-AUY9227
iGMDRD150RITA9
iGMDRD427ABT7376
iGMDRD594AZD-80551
iGMDRD605AZD64821
iGMDRD511CHEMBL3993795
iGMDRD280CYTOCHALASIN B4
iGMDRD123Isoevodiamine8
iGMDRD351GW843682X4
iGMDRD237ABT-7517

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXP1

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