FOXP1
Summary: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box P1 | MIM:605515 | Ensembl:ENSG00000114861 | HGNC:HGNC:3823 | PA28241 | 3p13 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in FOXP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0002903 | negative regulation of B cell apoptotic process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IDA | GO:0030316 | osteoclast differentiation |
| BP | IDA | GO:0032496 | response to lipopolysaccharide |
| BP | IDA | GO:0032680 | regulation of tumor necrosis factor production |
| BP | TAS | GO:0035019 | somatic stem cell population maintenance |
| BP | IDA | GO:0035926 | chemokine (C-C motif) ligand 2 secretion |
| BP | IDA | GO:0036035 | osteoclast development |
| BP | IDA | GO:0042116 | macrophage activation |
| BP | IDA | GO:0042117 | monocyte activation |
| BP | IMP | GO:0042118 | endothelial cell activation |
| BP | IDA | GO:0045655 | regulation of monocyte differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IDA | GO:0050706 | regulation of interleukin-1 beta secretion |
| BP | IDA | GO:0050727 | regulation of inflammatory response |
| BP | IDA | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| BP | ISS | GO:0061470 | T follicular helper cell differentiation |
| BP | ISS | GO:0072619 | interleukin-21 secretion |
| BP | IDA | GO:1900424 | regulation of defense response to bacterium |
| BP | IDA | GO:1901256 | regulation of macrophage colony-stimulating factor production |
| BP | IMP | GO:1901509 | regulation of endothelial tube morphogenesis |
| BP | IDA | GO:2001182 | regulation of interleukin-12 secretion |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| MF | IMP | GO:0043621 | protein self-association |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0050681 | androgen receptor binding |
Gene expression in normal tissue: FOXP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD103 | SN-38 | 8 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD200 | STF62247 | 1 |
| iGMDRD701 | NVP-AUY922 | 7 |
| iGMDRD150 | RITA | 9 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD511 | CHEMBL399379 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD123 | Isoevodiamine | 8 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD237 | ABT-751 | 7 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXP1
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