RNF130
Summary: The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ring finger protein 130 | Ensembl:ENSG00000113269 | HGNC:HGNC:18280 | PA134871556 | 5q35.3 |
GO terms in RNF130
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0012501 | programmed cell death |
| BP | IEA | GO:0016567 | protein ubiquitination |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: RNF130
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNF130
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 6 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD398 | Sepantronium | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNF130
CLASSFICATION
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