RNF130

Summary: The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namering finger protein 130
OMIM ID
Ensembl IDEnsembl:ENSG00000113269
HGNC IDHGNC:HGNC:18280
PHARMGKB IDPA134871556
Map Location5q35.3

GO terms in RNF130


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004842 ubiquitin-protein transferase activity
MF IEA GO:0046872 metal ion binding
MF IBA GO:0061630 ubiquitin protein ligase activity
BP IEA GO:0006915 apoptotic process
BP ISS GO:0012501 programmed cell death
BP IEA GO:0016567 protein ubiquitination
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Gene expression in normal tissue: RNF130

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined13Apoptosis regulation2Metabolism1Th17 cell differentiation1Biosynthesis of secondary metabolites1

Pathways in RNF130


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
reactome R-HSA-983169 Class I MHC mediated antigen processing & presentation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD150 RITA 6
iGMDRD427 ABT737 6
iGMDRD512 nutlin 3 3
iGMDRD772 BRD4770 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNF130

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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