IRAK4
Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:606883 Ensembl IDEnsembl:ENSG00000198001 HGNC IDHGNC:HGNC:17967 PHARMGKB IDPA134914577 Map Location12q12 |
GO terms in IRAK4
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0001816 | cytokine production |
BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
BP | IMP | GO:0002446 | neutrophil mediated immunity |
BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
BP | IEA | GO:0007254 | JNK cascade |
Gene expression in normal tissue: IRAK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRAK4
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
wikipathways | WP195 | IL-1 signaling pathway |
wikipathways | WP2324 | AGE-RAGE pathway |
wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
wikipathways | WP3851 | TLR4 Signaling and Tolerance |
wikipathways | WP3858 | Toll-like Receptor Signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in IRAK4
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |