IRAK4


Summary: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

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GO terms in IRAK4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001816 cytokine production
BP IBA GO:0002224 toll-like receptor signaling pathway
BP TAS GO:0002224 toll-like receptor signaling pathway
BP IMP GO:0002446 neutrophil mediated immunity
BP TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway
BP IEA GO:0007254 JNK cascade
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Gene expression in normal tissue: IRAK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined11IGFR signaling1Cell cycle1Chromatin other1Other, kinases1Biosynthesis of secondary metabolites1Apoptosis regulation1

Pathways in IRAK4


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Database
Pathway ID
Pathway Des.
wikipathways WP1449 Regulation of toll-like receptor signaling pathway
wikipathways WP195 IL-1 signaling pathway
wikipathways WP2324 AGE-RAGE pathway
wikipathways WP2637 Structural Pathway of Interleukin 1 (IL-1)
wikipathways WP3851 TLR4 Signaling and Tolerance
wikipathways WP3858 Toll-like Receptor Signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD782 DC-45-A2 2
iGMDRD434 BMS-536924 1
iGMDRD267 Oligomycin A 2
iGMDRD52 Rotenone 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRAK4

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Cancer
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Clinical Response
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