PTK7
Summary: This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine kinase 7 (inactive) | MIM:601890 | Ensembl:ENSG00000112655 | HGNC:HGNC:9618 | PA33961 | 6p21.1 |
GO terms in PTK7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | NAS | GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway |
| BP | IBA | GO:0001736 | establishment of planar polarity |
| BP | IEA | GO:0001736 | establishment of planar polarity |
| BP | IEA | GO:0003281 | ventricular septum development |
| BP | IBA | GO:0003401 | axis elongation |
| BP | IEA | GO:0003401 | axis elongation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0042060 | wound healing |
| BP | IEA | GO:0045198 | establishment of epithelial cell apical/basal polarity |
| BP | IEA | GO:0060026 | convergent extension |
| BP | IBA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0060070 | canonical Wnt signaling pathway |
| BP | IEA | GO:0060484 | lung-associated mesenchyme development |
| BP | IEA | GO:0060976 | coronary vasculature development |
| BP | IMP | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0090103 | cochlea morphogenesis |
| BP | IEA | GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005911 | cell-cell junction |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | HDA | GO:0005925 | focal adhesion |
Gene expression in normal tissue: PTK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTK7
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD150 | RITA | 8 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD105 | Triptolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTK7
CLASSFICATION
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