MINK1
Summary: This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| misshapen like kinase 1 | MIM:609426 | Ensembl:ENSG00000141503 | HGNC:HGNC:17565 | PA134910641 | 17p13.2 |
GO terms in MINK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005524 | ATP binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IMP | GO:0001952 | regulation of cell-matrix adhesion |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | ISS | GO:0007268 | chemical synaptic transmission |
| BP | ISS | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0022407 | regulation of cell-cell adhesion |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IMP | GO:0030033 | microvillus assembly |
| BP | IMP | GO:0030334 | regulation of cell migration |
| BP | IBA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IMP | GO:0031532 | actin cytoskeleton reorganization |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | ISS | GO:0046330 | positive regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | ISS | GO:0048813 | dendrite morphogenesis |
| BP | ISS | GO:1900745 | positive regulation of p38MAPK cascade |
| BP | ISS | GO:2000311 | regulation of AMPA receptor activity |
Gene expression in normal tissue: MINK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MINK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3404 | Oxidative Stress Induced Senescence |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD268 | Cerulenin | 6 |
| iGMDRD23 | Gossypol | 9 |
| iGMDRD524 | ISX-9 | 4 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD201 | SKI II | 7 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD147 | Prima-1 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MINK1
CLASSFICATION
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