MINK1

Summary: This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemisshapen like kinase 1
OMIM IDMIM:609426
Ensembl IDEnsembl:ENSG00000141503
HGNC IDHGNC:HGNC:17565
PHARMGKB IDPA134910641
Map Location17p13.2

GO terms in MINK1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004672 protein kinase activity
MF IBA GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF ISS GO:0005524 ATP binding
CC IBA GO:0005737 cytoplasm
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Gene expression in normal tissue: MINK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined34Apoptosis regulation3Chromatin histone acetylation2Cell cycle1Protein stability and degradation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Biosynthesis of secondary metabolites1RTK signaling1Other, kinases1

Pathways in MINK1


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Database
Pathway ID
Pathway Des.
wikipathways WP3404 Oxidative Stress Induced Senescence
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP481 Insulin Signaling
netpath Pathway_EGFR1 EGFR1
reactome R-HSA-2262752 Cellular responses to stress
reactome R-HSA-2559580 Oxidative Stress Induced Senescence
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD268 Cerulenin 6
iGMDRD23 Gossypol 9
iGMDRD524 ISX-9 4
iGMDRD444 Tivantinib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MINK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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