CYP3A4
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:124010 Ensembl IDEnsembl:ENSG00000160868 HGNC IDHGNC:HGNC:2637 PHARMGKB IDPA130 Map Location7q22.1 | |||||
GO terms in CYP3A4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004497 | monooxygenase activity |
| MF | ISS | GO:0004497 | monooxygenase activity |
| MF | TAS | GO:0004497 | monooxygenase activity |
| MF | IDA | GO:0005496 | steroid binding |
| MF | IDA | GO:0005506 | iron ion binding |
| MF | IMP | GO:0008395 | steroid hydroxylase activity |
Gene expression in normal tissue: CYP3A4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYP3A4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1604 | Codeine and Morphine Metabolism |
| wikipathways | WP206 | Fatty Acid Omega Oxidation |
| wikipathways | WP2289 | Drug Induction of Bile Acid Pathway |
| wikipathways | WP229 | Irinotecan Pathway |
| wikipathways | WP259 | Nifedipine Activity |
| wikipathways | WP2646 | Lidocaine metabolism |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYP3A4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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