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YES1

Summary: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameYES proto-oncogene 1, Src family tyrosine kinase OMIM IDMIM:164880 Ensembl IDEnsembl:ENSG00000176105 HGNC IDHGNC:HGNC:12841 PHARMGKB IDPA37432 Map Location18p11.32

Gene Categories:

KINASE CLINICALLY ACTIONABLE DRUGGABLE GENOME TYROSINE KINASE

GO terms in YES1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005794	Golgi apparatus
CC	IEA	GO:0005815	microtubule organizing center
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005884	actin filament
CC	IDA	GO:0005886	plasma membrane

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Gene expression in normal tissue: YES1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in YES1

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Database	Pathway ID	Pathway Des.
pid	alphasynuclein_pathway	Alpha-synuclein signaling
pid	cdc42_pathway	CDC42 signaling events
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	epha_fwdpathway	EPHA forward signaling
pid	ephrinbrevpathway	Ephrin B reverse signaling
pid	fak_pathway	Signaling events mediated by focal adhesion kinase

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD144	NSC95397	5
iGMDRD150	RITA	2
iGMDRD152	179324-69-7	3
iGMDRD61	Kinetin riboside	6

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in YES1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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