YES1
Summary: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| YES proto-oncogene 1, Src family tyrosine kinase | MIM:164880 | Ensembl:ENSG00000176105 | HGNC:HGNC:12841 | PA37432 | 18p11.32 |
GO terms in YES1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IEA | GO:0010827 | regulation of glucose transmembrane transport |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | TAS | GO:0043114 | regulation of vascular permeability |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0044325 | ion channel binding |
Gene expression in normal tissue: YES1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in YES1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | glypican_1pathway | Glypican 1 network |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Wnt | Wnt |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8940973 | RUNX2 regulates osteoblast differentiation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD150 | RITA | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in YES1
CLASSFICATION
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