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SBDS

Summary: This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameSBDS, ribosome maturation factor OMIM IDMIM:607444 Ensembl IDEnsembl:ENSG00000126524 HGNC IDHGNC:HGNC:19440 PHARMGKB IDPA134978742 Map Location7q11.21

GO terms in SBDS

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	HDA	GO:0003723	RNA binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008017	microtubule binding
MF	IDA	GO:0019843	rRNA binding
MF	IDA	GO:0043022	ribosome binding
BP	IEA	GO:0001833	inner cell mass cell proliferation

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Gene expression in normal tissue: SBDS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SBDS

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Database	Pathway ID	Pathway Des.
kegg	hsa03008	Ribosome biogenesis in eukaryotes - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD150	RITA	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SBDS

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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