LRRK1
Summary: This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:610986 Ensembl IDEnsembl:ENSG00000154237 HGNC IDHGNC:HGNC:18608 PHARMGKB IDPA134892363 Map Location15q26.3 | |||||
GO terms in LRRK1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0036035 | osteoclast development |
| BP | IEA | GO:0045453 | bone resorption |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| BP | IGI | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
Gene expression in normal tissue: LRRK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRRK1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRRK1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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