LRRK1
Summary: This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine rich repeat kinase 1 | MIM:610986 | Ensembl:ENSG00000154237 | HGNC:HGNC:18608 | PA134892363 | 15q26.3 |
GO terms in LRRK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0036035 | osteoclast development |
| BP | IEA | GO:0045453 | bone resorption |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| BP | IGI | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:1902533 | positive regulation of intracellular signal transduction |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: LRRK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRRK1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD524 | ISX-9 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRRK1
CLASSFICATION
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