MCM4
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| minichromosome maintenance complex component 4 | MIM:602638 | Ensembl:ENSG00000104738 | HGNC:HGNC:6947 | PA30694 | 8q11.21 |
GO terms in MCM4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003697 | single-stranded DNA binding |
| MF | IDA | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | NAS | GO:0006260 | DNA replication |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IEA | GO:0006268 | DNA unwinding involved in DNA replication |
| BP | IEA | GO:0006270 | DNA replication initiation |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0042555 | MCM complex |
Gene expression in normal tissue: MCM4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MCM4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | mcmpathway | cdk regulation of dna replication |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-176974 | Unwinding of DNA |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-68867 | Assembly of the pre-replicative complex |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68949 | Orc1 removal from chromatin |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2361 | Gastric Cancer Network 1 |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP466 | DNA Replication |
| pid | cmyb_pathway | C-MYB transcription factor network |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD77 | Itraconazole | 9 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD150 | RITA | 8 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MCM4
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