MLLT10
Summary: This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MLLT10, histone lysine methyltransferase DOT1L cofactor | MIM:602409 | Ensembl:ENSG00000078403 | HGNC:HGNC:16063 | PA30849 | 10p12.31 |
GO terms in MLLT10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0031491 | nucleosome binding |
| MF | IPI | GO:0042393 | histone binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: MLLT10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MLLT10
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD107 | Valdecoxib | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD150 | RITA | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD289 | Parthenolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MLLT10
CLASSFICATION
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