LIN9


Summary: This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lin-9 DREAM MuvB core complex componentMIM:609375Ensembl:ENSG00000183814HGNC:HGNC:30830PA1349707711q42.12

Gene Categories:

TUMOR SUPPRESSOR

GO terms in LIN9


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0017053transcriptional repressor complex
BPIBAGO:0000003reproduction
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007049cell cycle
BPIBAGO:0051726regulation of cell cycle
BPTASGO:0051726regulation of cell cycle
BPIEAGO:0071897DNA biosynthetic process
MFIBAGO:0003677DNA binding
MFIPIGO:0005515protein binding

Gene expression in normal tissue: LIN9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LIN9


DatabasePathway IDPathway Des.
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362277Transcription of E2F targets under negative control by DREAM complex
reactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-156711Polo-like kinase mediated events
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69242S Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
wikipathwaysWP2361Gastric Cancer Network 1
kegghsa04218Cellular senescence - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin6
iGMDRD255SB2250023
iGMDRD260FQI-23
iGMDRD138PX 126
iGMDRD251ML1623
iGMDRD246NPC263
iGMDRD64Parbendazole6
iGMDRD886Compound 1541A3
iGMDRD286Nsc 6328393
iGMDRD414MST-3126
iGMDRD871BRD63683
iGMDRD484Pluripotin3
iGMDRD144NSC953976
iGMDRD150RITA3
iGMDRD889Compound 7d-cis6
iGMDRD883CIL55A4
iGMDRD945ML2146
iGMDRD280CYTOCHALASIN B9
iGMDRD193Fqi16
iGMDRD446LY 21832403

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LIN9

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