ASH2L
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ASH2 like, histone lysine methyltransferase complex subunit | MIM:604782 | Ensembl:ENSG00000129691 | HGNC:HGNC:744 | PA25044 | 8p11.23 |
GO terms in ASH2L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IBA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| MF | IDA | GO:0042800 | histone methyltransferase activity (H3-K4 specific) |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:1990188 | euchromatin binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005719 | nuclear euchromatin |
| CC | IDA | GO:0035097 | histone methyltransferase complex |
| CC | IPI | GO:0035097 | histone methyltransferase complex |
| CC | IDA | GO:0044666 | MLL3/4 complex |
| CC | IBA | GO:0048188 | Set1C/COMPASS complex |
| CC | IDA | GO:0048188 | Set1C/COMPASS complex |
| CC | IEA | GO:0071339 | MLL1 complex |
| BP | IBA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | NAS | GO:0030097 | hemopoiesis |
| BP | IDA | GO:0043627 | response to estrogen |
| BP | TAS | GO:0045652 | regulation of megakaryocyte differentiation |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0051568 | histone H3-K4 methylation |
| BP | IDA | GO:0051568 | histone H3-K4 methylation |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
Gene expression in normal tissue: ASH2L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ASH2L
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ASH2L
CLASSFICATION
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