POU5F1B
Summary: This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| POU class 5 homeobox 1B | MIM:615739 | Ensembl:ENSG00000212993 | HGNC:HGNC:9223 | PA33547 | 8q24.21 |
GO terms in POU5F1B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
Gene expression in normal tissue: POU5F1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POU5F1B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 8 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD297 | Austocystin D | 7 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POU5F1B
CLASSFICATION
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