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GSK3B

Summary: The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
glycogen synthase kinase 3 beta	MIM:605004	Ensembl:ENSG00000082701	HGNC:HGNC:4617	PA29009	3q13.33

Gene Categories:

SERINE THREONINE KINASE KINASE TRANSCRIPTION FACTOR BINDING CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in GSK3B

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0001837	epithelial to mesenchymal transition
BP	IMP	GO:0001954	positive regulation of cell-matrix adhesion
BP	IDA	GO:0005977	glycogen metabolic process
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0006468	protein phosphorylation
BP	IDA	GO:0006983	ER overload response
BP	NAS	GO:0007212	dopamine receptor signaling pathway
BP	ISS	GO:0007623	circadian rhythm
BP	ISS	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0010822	positive regulation of mitochondrion organization
BP	TAS	GO:0016055	Wnt signaling pathway
BP	IDA	GO:0018105	peptidyl-serine phosphorylation
BP	IDA	GO:0018107	peptidyl-threonine phosphorylation
BP	IMP	GO:0021766	hippocampus development
BP	ISS	GO:0030010	establishment of cell polarity
BP	TAS	GO:0030010	establishment of cell polarity
BP	ISS	GO:0030011	maintenance of cell polarity
BP	TAS	GO:0030011	maintenance of cell polarity
BP	ISS	GO:0030516	regulation of axon extension
BP	IDA	GO:0031175	neuron projection development
BP	IMP	GO:0031333	negative regulation of protein complex assembly
BP	IDA	GO:0031334	positive regulation of protein complex assembly
BP	IDA	GO:0032091	negative regulation of protein binding
BP	ISS	GO:0032092	positive regulation of protein binding
BP	IC	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BP	IMP	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BP	TAS	GO:0032515	negative regulation of phosphoprotein phosphatase activity
BP	IMP	GO:0032886	regulation of microtubule-based process
BP	IDA	GO:0035556	intracellular signal transduction
BP	TAS	GO:0035556	intracellular signal transduction
BP	ISS	GO:0036016	cellular response to interleukin-3
BP	IDA	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043547	positive regulation of GTPase activity
BP	TAS	GO:0045719	negative regulation of glycogen biosynthetic process
BP	IC	GO:0045732	positive regulation of protein catabolic process
BP	IDA	GO:0046777	protein autophosphorylation
BP	IDA	GO:0046827	positive regulation of protein export from nucleus
BP	ISS	GO:0048814	regulation of dendrite morphogenesis
BP	ISS	GO:0050770	regulation of axonogenesis
BP	IC	GO:0060070	canonical Wnt signaling pathway
BP	IDA	GO:0060070	canonical Wnt signaling pathway
BP	TAS	GO:0060070	canonical Wnt signaling pathway
BP	NAS	GO:0060079	excitatory postsynaptic potential
BP	IMP	GO:0070507	regulation of microtubule cytoskeleton organization
BP	ISS	GO:0070507	regulation of microtubule cytoskeleton organization
BP	IMP	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
BP	IMP	GO:0071109	superior temporal gyrus development
BP	IC	GO:0090090	negative regulation of canonical Wnt signaling pathway
BP	TAS	GO:0090090	negative regulation of canonical Wnt signaling pathway
BP	ISS	GO:0097191	extrinsic apoptotic signaling pathway
BP	ISS	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
BP	ISS	GO:0106028	neuron projection retraction
BP	TAS	GO:1900034	regulation of cellular response to heat
BP	ISS	GO:1900181	negative regulation of protein localization to nucleus
BP	ISS	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
BP	IDA	GO:1901215	negative regulation of neuron death
BP	IDA	GO:1901216	positive regulation of neuron death
BP	ISS	GO:1901984	negative regulation of protein acetylation
BP	TAS	GO:1904339	negative regulation of dopaminergic neuron differentiation
BP	ISS	GO:1904646	cellular response to amyloid-beta
BP	IMP	GO:1904781	positive regulation of protein localization to centrosome
BP	TAS	GO:1904885	beta-catenin destruction complex assembly
BP	TAS	GO:1904886	beta-catenin destruction complex disassembly
BP	TAS	GO:2000077	negative regulation of type B pancreatic cell development
BP	TAS	GO:2000466	negative regulation of glycogen (starch) synthase activity
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IEA	GO:0005739	mitochondrion
CC	IDA	GO:0005813	centrosome
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	ISS	GO:0030424	axon
CC	ISS	GO:0030425	dendrite
CC	IDA	GO:0030877	beta-catenin destruction complex
CC	TAS	GO:0030877	beta-catenin destruction complex
CC	IEA	GO:0098794	postsynapse
CC	TAS	GO:1990909	Wnt signalosome
MF	IPI	GO:0001085	RNA polymerase II transcription factor binding
MF	IPI	GO:0002020	protease binding
MF	IDA	GO:0002039	p53 binding
MF	TAS	GO:0004672	protein kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	ISS	GO:0004674	protein serine/threonine kinase activity
MF	NAS	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IPI	GO:0008013	beta-catenin binding
MF	IDA	GO:0016301	kinase activity
MF	TAS	GO:0016301	kinase activity
MF	IPI	GO:0019901	protein kinase binding
MF	IPI	GO:0031625	ubiquitin protein ligase binding
MF	IPI	GO:0034236	protein kinase A catalytic subunit binding
MF	IPI	GO:0034452	dynactin binding
MF	IDA	GO:0050321	tau-protein kinase activity
MF	IPI	GO:0051059	NF-kappaB binding

Gene expression in normal tissue: GSK3B

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GSK3B

Database	Pathway ID	Pathway Des.
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP138	Androgen receptor signaling pathway
wikipathways	WP1541	Energy Metabolism
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP179	Cell Cycle
wikipathways	WP2034	Leptin signaling pathway
wikipathways	WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways	WP2037	Prolactin Signaling Pathway
wikipathways	WP2038	Regulation of Microtubule Cytoskeleton
wikipathways	WP205	IL-7 Signaling Pathway
wikipathways	WP2059	Alzheimers Disease
wikipathways	WP2064	Neural Crest Differentiation
wikipathways	WP2112	IL17 signaling pathway
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP2406	Cardiac Progenitor Differentiation
wikipathways	WP2583	T-Cell Receptor and Co-stimulatory Signaling
wikipathways	WP2593	JAK-STAT
wikipathways	WP2795	Cardiac Hypertrophic Response
wikipathways	WP2804	Hair Follicle Development- Induction (Part 1 of 3)
wikipathways	WP306	Focal Adhesion
wikipathways	WP3286	Copper homeostasis
wikipathways	WP3298	Melatonin metabolism and effects
wikipathways	WP363	Wnt Signaling Pathway
wikipathways	WP364	IL-6 signaling pathway
wikipathways	WP3658	Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathways	WP3664	Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds
wikipathways	WP3680	Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathways	WP3844	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathways	WP3850	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathways	WP3863	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathways	WP3872	Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP3931	ESC Pluripotency Pathways
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP3981	miRNA regulation of prostate cancer signaling pathways
wikipathways	WP399	Wnt Signaling Pathway and Pluripotency
wikipathways	WP4141	PI3K-AKT-mTOR - VitD3 Signalling
wikipathways	WP4155	Endometrial cancer
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP428	Wnt Signaling Pathway
wikipathways	WP481	Insulin Signaling
wikipathways	WP500	Glycogen Metabolism
wikipathways	WP61	Notch Signaling Pathway
wikipathways	WP615	Senescence and Autophagy in Cancer
wikipathways	WP673	ErbB Signaling Pathway
wikipathways	WP710	DNA Damage Response (only ATM dependent)
pid	ar_tf_pathway	Regulation of Androgen receptor activity
pid	aurora_a_pathway	Aurora A signaling
pid	betacatenin_deg_pathway	Degradation of beta catenin
pid	cdc42_pathway	CDC42 signaling events
pid	deltanp63pathway	Validated transcriptional targets of deltaNp63 isoforms
pid	hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins
pid	ilk_pathway	Integrin-linked kinase signaling
pid	insulin_glucose_pathway	Insulin-mediated glucose transport
pid	kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pid	lkb1_pathway	LKB1 signaling events
pid	lysophospholipid_pathway	LPA receptor mediated events
pid	myc_pathway	C-MYC pathway
pid	nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes
pid	p53regulationpathway	p53 pathway
pid	pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
pid	pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma
pid	ps1pathway	Presenilin action in Notch and Wnt signaling
pid	reelinpathway	Reelin signaling pathway
pid	reg_gr_pathway	Glucocorticoid receptor regulatory network
pid	wnt_canonical_pathway	Canonical Wnt signaling pathway
netpath	Pathway_AndrogenReceptor	AndrogenReceptor
netpath	Pathway_BCR	BCR
netpath	Pathway_BDNF	BDNF
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_Gastrin	Gastrin
netpath	Pathway_IL-7	IL-7
netpath	Pathway_IL3	IL3
netpath	Pathway_IL5	IL5
netpath	Pathway_IL6	IL6
netpath	Pathway_KitReceptor	KitReceptor
netpath	Pathway_Leptin	Leptin
netpath	Pathway_Notch	Notch
netpath	Pathway_Prolactin	Prolactin
netpath	Pathway_TCR	TCR
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
netpath	Pathway_TWEAK	TWEAK
netpath	Pathway_Wnt	Wnt
kegg	hsa04012	ErbB signaling pathway - Homo sapiens (human)
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
kegg	hsa04150	mTOR signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04310	Wnt signaling pathway - Homo sapiens (human)
kegg	hsa04340	Hedgehog signaling pathway - Homo sapiens (human)
kegg	hsa04360	Axon guidance - Homo sapiens (human)
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04550	Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg	hsa04657	IL-17 signaling pathway - Homo sapiens (human)
kegg	hsa04660	T cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04662	B cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04728	Dopaminergic synapse - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa04916	Melanogenesis - Homo sapiens (human)
kegg	hsa04917	Prolactin signaling pathway - Homo sapiens (human)
kegg	hsa04919	Thyroid hormone signaling pathway - Homo sapiens (human)
kegg	hsa04931	Insulin resistance - Homo sapiens (human)
kegg	hsa04932	Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegg	hsa04934	Cushing,s syndrome - Homo sapiens (human)
kegg	hsa05010	Alzheimer,s disease - Homo sapiens (human)
kegg	hsa05160	Hepatitis C - Homo sapiens (human)
kegg	hsa05162	Measles - Homo sapiens (human)
kegg	hsa05164	Influenza A - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05213	Endometrial cancer - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
kegg	hsa05217	Basal cell carcinoma - Homo sapiens (human)
kegg	hsa05224	Breast cancer - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
biocarta	eif2pathway	regulation of eif2
biocarta	g1pathway	cell cycle: g1/s check point
biocarta	gsk3pathway	inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocarta	hespathway	segmentation clock
biocarta	igf1mtorpathway	skeletal muscle hypertrophy is regulated via akt-mtor pathway
biocarta	nfatpathway	nfat and hypertrophy of the heart
biocarta	p35alzheimerspathway	deregulation of cdk5 in alzheimers disease
biocarta	pitx2pathway	multi-step regulation of transcription by pitx2
biocarta	ptdinspathway	phosphoinositides and their downstream targets
biocarta	wntpathway	wnt signaling pathway
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1643685	Disease
reactome	R-HSA-195253	Degradation of beta-catenin by the destruction complex
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-196299	Beta-catenin phosphorylation cascade
reactome	R-HSA-198323	AKT phosphorylates targets in the cytosol
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-212165	Epigenetic regulation of gene expression
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2219528	PI3K/AKT Signaling in Cancer
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-3371453	Regulation of HSF1-mediated heat shock response
reactome	R-HSA-3371556	Cellular response to heat stress
reactome	R-HSA-373755	Semaphorin interactions
reactome	R-HSA-399956	CRMPs in Sema3A signaling
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactome	R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactome	R-HSA-4791275	Signaling by WNT in cancer
reactome	R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling
reactome	R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
reactome	R-HSA-4839744	truncated APC mutants destabilize the destruction complex
reactome	R-HSA-4839748	AMER1 mutants destabilize the destruction complex
reactome	R-HSA-5250913	Positive epigenetic regulation of rRNA expression
reactome	R-HSA-5250924	B-WICH complex positively regulates rRNA expression
reactome	R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin
reactome	R-HSA-5358351	Signaling by Hedgehog
reactome	R-HSA-5358351	Signaling by Hedgehog
reactome	R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5467337	APC truncation mutants have impaired AXIN binding
reactome	R-HSA-5467340	AXIN missense mutants destabilize the destruction complex
reactome	R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex
reactome	R-HSA-5610783	Degradation of GLI2 by the proteasome
reactome	R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome
reactome	R-HSA-5610787	Hedgehog 'off' state
reactome	R-HSA-5610787	Hedgehog 'off' state
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer
reactome	R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1
reactome	R-HSA-69242	S Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D
reactome	R-HSA-8878166	Transcriptional regulation by RUNX2
reactome	R-HSA-8939902	Regulation of RUNX2 expression and activity
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9006925	Intracellular signaling by second messengers

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD466	Chaetocin	3
iGMDRD64	Parbendazole	3
iGMDRD123	Isoevodiamine	4
iGMDRD314	Tanespimycin	2
iGMDRD193	Fqi1	3
iGMDRD237	ABT-751	1
iGMDRD483	SCH-529074	3
iGMDRD885	Compound 110	3
iGMDRD150	RITA	3
iGMDRD782	DC-45-A2	1
iGMDRD434	BMS-536924	3
iGMDRD424	Tamatinib	6
iGMDRD171	Pemetrexed	1
iGMDRD1008	SR-II-138A	3
iGMDRD137	Indisulam	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSK3B

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.