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GSK3B

Summary: The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameglycogen synthase kinase 3 beta OMIM IDMIM:605004 Ensembl IDEnsembl:ENSG00000082701 HGNC IDHGNC:HGNC:4617 PHARMGKB IDPA29009 Map Location3q13.33

Gene Categories:

SERINE THREONINE KINASE KINASE TRANSCRIPTION FACTOR BINDING CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in GSK3B

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0001837	epithelial to mesenchymal transition
BP	IMP	GO:0001954	positive regulation of cell-matrix adhesion
BP	IDA	GO:0005977	glycogen metabolic process
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0006468	protein phosphorylation
BP	IDA	GO:0006983	ER overload response

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Gene expression in normal tissue: GSK3B

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GSK3B

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Database	Pathway ID	Pathway Des.
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP138	Androgen receptor signaling pathway
wikipathways	WP1541	Energy Metabolism
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP179	Cell Cycle
wikipathways	WP2034	Leptin signaling pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD466	Chaetocin	3
iGMDRD64	Parbendazole	3
iGMDRD123	Isoevodiamine	4
iGMDRD314	Tanespimycin	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSK3B

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.