TNFRSF10B
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 10b | MIM:603612 | Ensembl:ENSG00000120889 | HGNC:HGNC:11905 | PA36598 | 8p21.3 |
GO terms in TNFRSF10B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | NAS | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | NAS | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | NAS | GO:0042981 | regulation of apoptotic process |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | TAS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | TAS | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| CC | IEA | GO:0005622 | intracellular |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0038023 | signaling receptor activity |
| MF | NAS | GO:0045569 | TRAIL binding |
Gene expression in normal tissue: TNFRSF10B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF10B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
| wikipathways | WP707 | DNA Damage Response |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | trail_pathway | TRAIL signaling pathway |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5218900 | CASP8 activity is inhibited |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands |
| reactome | R-HSA-69416 | Dimerization of procaspase-8 |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75158 | TRAIL signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD414 | MST-312 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF10B
CLASSFICATION
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