GLI3

Summary: This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameGLI family zinc finger 3
OMIM IDMIM:165240
Ensembl IDEnsembl:ENSG00000106571
HGNC IDHGNC:HGNC:4319
PHARMGKB IDPA28722
Map Location7p14.1

GO terms in GLI3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0001656 metanephros development
BP IEA GO:0001658 branching involved in ureteric bud morphogenesis
BP IEA GO:0001701 in utero embryonic development
BP IEA GO:0002052 positive regulation of neuroblast proliferation
BP IEA GO:0006366 transcription by RNA polymerase II
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Gene expression in normal tissue: GLI3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 35undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 9undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined21Apoptosis regulation1Mitosis1

Pathways in GLI3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-5358351 Signaling by Hedgehog
reactome R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
reactome R-HSA-5610787 Hedgehog 'off' state
reactome R-HSA-5632684 Hedgehog 'on' state
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD60 Quinoclamine 3
iGMDRD263 AACOCF3 1
iGMDRD147 Prima-1 1
iGMDRD300 Tozasertib 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLI3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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