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LYN

Summary: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
LYN proto-oncogene, Src family tyrosine kinase	MIM:165120	Ensembl:ENSG00000254087	HGNC:HGNC:6735	PA30498	8q12.1

Gene Categories:

SERINE THREONINE KINASE KINASE PROTEASE TYROSINE KINASE DRUGGABLE GENOME LIPID KINASE DRUG RESISTANCE

GO terms in LYN

Term Type	Evidence Type	GO Term ID	GO Des.
MF	EXP	GO:0004713	protein tyrosine kinase activity
MF	IDA	GO:0004713	protein tyrosine kinase activity
MF	TAS	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	TAS	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IEA	GO:0005161	platelet-derived growth factor receptor binding
MF	IEA	GO:0005178	integrin binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	NAS	GO:0016301	kinase activity
MF	IEA	GO:0017124	SH3 domain binding
MF	IEA	GO:0031625	ubiquitin protein ligase binding
MF	IEA	GO:0043015	gamma-tubulin binding
MF	IEA	GO:0043208	glycosphingolipid binding
MF	IPI	GO:0044325	ion channel binding
MF	IPI	GO:0046875	ephrin receptor binding
MF	IEA	GO:0051219	phosphoprotein binding
MF	IPI	GO:0140031	phosphorylation-dependent protein binding
CC	IDA	GO:0005634	nucleus
CC	ISS	GO:0005634	nucleus
CC	ISS	GO:0005737	cytoplasm
CC	IEA	GO:0005758	mitochondrial intermembrane space
CC	IDA	GO:0005794	Golgi apparatus
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IEA	GO:0005913	cell-cell adherens junction
CC	IEA	GO:0014069	postsynaptic density
CC	IEA	GO:0030061	mitochondrial crista
CC	IBA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	IEA	GO:0034666	integrin alpha2-beta1 complex
CC	IEA	GO:0042629	mast cell granule
CC	IDA	GO:0043231	intracellular membrane-bounded organelle
CC	IDA	GO:0045121	membrane raft
CC	ISS	GO:0045121	membrane raft
CC	IDA	GO:0048471	perinuclear region of cytoplasm
CC	HDA	GO:0070062	extracellular exosome
BP	ISS	GO:0001782	B cell homeostasis
BP	ISS	GO:0001817	regulation of cytokine production
BP	TAS	GO:0001932	regulation of protein phosphorylation
BP	ISS	GO:0001933	negative regulation of protein phosphorylation
BP	IGI	GO:0001934	positive regulation of protein phosphorylation
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	IEA	GO:0002250	adaptive immune response
BP	IBA	GO:0002431	Fc receptor mediated stimulatory signaling pathway
BP	ISS	GO:0002431	Fc receptor mediated stimulatory signaling pathway
BP	IBA	GO:0002513	tolerance induction to self antigen
BP	ISS	GO:0002513	tolerance induction to self antigen
BP	TAS	GO:0002513	tolerance induction to self antigen
BP	IEA	GO:0002553	histamine secretion by mast cell
BP	IBA	GO:0002576	platelet degranulation
BP	ISS	GO:0002576	platelet degranulation
BP	IEA	GO:0002762	negative regulation of myeloid leukocyte differentiation
BP	ISS	GO:0002768	immune response-regulating cell surface receptor signaling pathway
BP	TAS	GO:0002768	immune response-regulating cell surface receptor signaling pathway
BP	ISS	GO:0002774	Fc receptor mediated inhibitory signaling pathway
BP	IBA	GO:0002902	regulation of B cell apoptotic process
BP	IDA	GO:0006468	protein phosphorylation
BP	IBA	GO:0006974	cellular response to DNA damage stimulus
BP	IDA	GO:0006974	cellular response to DNA damage stimulus
BP	IEA	GO:0006991	response to sterol depletion
BP	TAS	GO:0007165	signal transduction
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IMP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	TAS	GO:0007596	blood coagulation
BP	ISS	GO:0008284	positive regulation of cell proliferation
BP	IMP	GO:0008285	negative regulation of cell proliferation
BP	IEA	GO:0009636	response to toxic substance
BP	ISS	GO:0009725	response to hormone
BP	IEA	GO:0009743	response to carbohydrate
BP	IMP	GO:0010976	positive regulation of neuron projection development
BP	IEA	GO:0014003	oligodendrocyte development
BP	IEA	GO:0014070	response to organic cyclic compound
BP	IEA	GO:0016032	viral process
BP	IDA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IBA	GO:0030154	cell differentiation
BP	TAS	GO:0030168	platelet activation
BP	ISS	GO:0030218	erythrocyte differentiation
BP	IEA	GO:0030335	positive regulation of cell migration
BP	IBA	GO:0030889	negative regulation of B cell proliferation
BP	IBA	GO:0031175	neuron projection development
BP	IEA	GO:0031175	neuron projection development
BP	TAS	GO:0031295	T cell costimulation
BP	ISS	GO:0031663	lipopolysaccharide-mediated signaling pathway
BP	IEA	GO:0031668	cellular response to extracellular stimulus
BP	IEA	GO:0032868	response to insulin
BP	ISS	GO:0033003	regulation of mast cell activation
BP	IMP	GO:0033628	regulation of cell adhesion mediated by integrin
BP	ISS	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway
BP	ISS	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
BP	IEA	GO:0034605	cellular response to heat
BP	IBA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	TAS	GO:0038095	Fc-epsilon receptor signaling pathway
BP	TAS	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
BP	IBA	GO:0042127	regulation of cell proliferation
BP	IEA	GO:0042493	response to drug
BP	ISS	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
BP	IEA	GO:0043200	response to amino acid
BP	IBA	GO:0043304	regulation of mast cell degranulation
BP	ISS	GO:0043304	regulation of mast cell degranulation
BP	ISS	GO:0043407	negative regulation of MAP kinase activity
BP	IEA	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
BP	IBA	GO:0045087	innate immune response
BP	ISS	GO:0045646	regulation of erythrocyte differentiation
BP	IDA	GO:0046777	protein autophosphorylation
BP	TAS	GO:0048013	ephrin receptor signaling pathway
BP	IEA	GO:0048678	response to axon injury
BP	IEA	GO:0050663	cytokine secretion
BP	IEA	GO:0050707	regulation of cytokine secretion
BP	IEA	GO:0050727	regulation of inflammatory response
BP	TAS	GO:0050777	negative regulation of immune response
BP	IEA	GO:0050853	B cell receptor signaling pathway
BP	IBA	GO:0050855	regulation of B cell receptor signaling pathway
BP	ISS	GO:0050855	regulation of B cell receptor signaling pathway
BP	IEA	GO:0050861	positive regulation of B cell receptor signaling pathway
BP	TAS	GO:0050900	leukocyte migration
BP	IDA	GO:0051272	positive regulation of cellular component movement
BP	IEA	GO:0051279	regulation of release of sequestered calcium ion into cytosol
BP	IEA	GO:0060252	positive regulation of glial cell proliferation
BP	IEA	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway
BP	TAS	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
BP	IDA	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade
BP	ISS	GO:0070372	regulation of ERK1 and ERK2 cascade
BP	ISS	GO:0070373	negative regulation of ERK1 and ERK2 cascade
BP	IEA	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation
BP	IBA	GO:0070667	negative regulation of mast cell proliferation
BP	ISS	GO:0070667	negative regulation of mast cell proliferation
BP	IMP	GO:0070668	positive regulation of mast cell proliferation
BP	IMP	GO:0071300	cellular response to retinoic acid
BP	IMP	GO:0090025	regulation of monocyte chemotaxis
BP	IBA	GO:0090330	regulation of platelet aggregation
BP	ISS	GO:0090330	regulation of platelet aggregation
BP	IBA	GO:0097028	dendritic cell differentiation
BP	ISS	GO:0097028	dendritic cell differentiation
BP	ISS	GO:1902532	negative regulation of intracellular signal transduction
BP	IMP	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
BP	IBA	GO:2000670	positive regulation of dendritic cell apoptotic process
BP	ISS	GO:2000670	positive regulation of dendritic cell apoptotic process

Gene expression in normal tissue: LYN

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LYN

Database	Pathway ID	Pathway Des.
biocarta	bcrpathway	bcr signaling pathway
biocarta	fcer1pathway	fc epsilon receptor i signaling in mast cells
biocarta	ptdinspathway	phosphoinositides and their downstream targets
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114604	GPVI-mediated activation cascade
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1433557	Signaling by SCF-KIT
reactome	R-HSA-1433557	Signaling by SCF-KIT
reactome	R-HSA-1433559	Regulation of KIT signaling
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-202733	Cell surface interactions at the vascular wall
reactome	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis
reactome	R-HSA-2029481	FCGR activation
reactome	R-HSA-210990	PECAM1 interactions
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization
reactome	R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization
reactome	R-HSA-2871796	FCERI mediated MAPK activation
reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
reactome	R-HSA-2871809	FCERI mediated Ca+2 mobilization
reactome	R-HSA-2871837	FCERI mediated NF-kB activation
reactome	R-HSA-388841	Costimulation by the CD28 family
reactome	R-HSA-389356	CD28 co-stimulation
reactome	R-HSA-389513	CTLA4 inhibitory signaling
reactome	R-HSA-3928662	EPHB-mediated forward signaling
reactome	R-HSA-3928662	EPHB-mediated forward signaling
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-453279	Mitotic G1-G1/S phases
reactome	R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling
reactome	R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling
reactome	R-HSA-5621480	Dectin-2 family
reactome	R-HSA-5621481	C-type lectin receptors (CLRs)
reactome	R-HSA-5621575	CD209 (DC-SIGN) signaling
reactome	R-HSA-5690714	CD22 mediated BCR regulation
reactome	R-HSA-69231	Cyclin D associated events in G1
reactome	R-HSA-69236	G1 Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-75892	Platelet Adhesion to exposed collagen
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-912631	Regulation of signaling by CBL
reactome	R-HSA-912631	Regulation of signaling by CBL
reactome	R-HSA-982772	Growth hormone receptor signaling
reactome	R-HSA-982772	Growth hormone receptor signaling
reactome	R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
reactome	R-HSA-983705	Signaling by the B Cell Receptor (BCR)
reactome	R-HSA-983705	Signaling by the B Cell Receptor (BCR)
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP2018	RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathways	WP2203	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP286	IL-3 Signaling Pathway
wikipathways	WP304	Kit receptor signaling pathway
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP3937	Microglia Pathogen Phagocytosis Pathway
smpdb	SMP00358	Fc Epsilon Receptor I Signaling in Mast Cells
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04064	NF-kappa B signaling pathway - Homo sapiens (human)
kegg	hsa04611	Platelet activation - Homo sapiens (human)
kegg	hsa04662	B cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04664	Fc epsilon RI signaling pathway - Homo sapiens (human)
kegg	hsa04666	Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegg	hsa04730	Long-term depression - Homo sapiens (human)
kegg	hsa05120	Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05203	Viral carcinogenesis - Homo sapiens (human)
pid	alphasynuclein_pathway	Alpha-synuclein signaling
pid	bcr_5pathway	BCR signaling pathway
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	epha_fwdpathway	EPHA forward signaling
pid	ephrinbrevpathway	Ephrin B reverse signaling
pid	epopathway	EPO signaling pathway
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	glypican_1pathway	Glypican 1 network
pid	gmcsf_pathway	GMCSF-mediated signaling events
pid	il5_pathway	IL5-mediated signaling events
pid	il8cxcr1_pathway	IL8- and CXCR1-mediated signaling events
pid	il8cxcr2_pathway	IL8- and CXCR2-mediated signaling events
pid	kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pid	lysophospholipid_pathway	LPA receptor mediated events
pid	p38alphabetapathway	Regulation of p38-alpha and p38-beta
pid	pdgfrbpathway	PDGFR-beta signaling pathway
pid	pi3kcipathway	Class I PI3K signaling events
pid	ptp1bpathway	Signaling events mediated by PTP1B
pid	txa2pathway	Thromboxane A2 receptor signaling
netpath	Pathway_BCR	BCR
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_IL2	IL2
netpath	Pathway_IL3	IL3
netpath	Pathway_IL5	IL5
netpath	Pathway_IL6	IL6
netpath	Pathway_KitReceptor	KitReceptor
netpath	Pathway_TCR	TCR

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD579	PF750	2
iGMDRD1008	SR-II-138A	3
iGMDRD126	Tipifarnib	2
iGMDRD781	Sirolimus	3
iGMDRD61	Kinetin riboside	3
iGMDRD193	Fqi1	2
iGMDRD446	LY 2183240	4
iGMDRD297	Austocystin D	3
iGMDRD280	CYTOCHALASIN B	2
iGMDRD318	PAC-1	2
iGMDRD187	BRD9876	5
iGMDRD171	Pemetrexed	4
iGMDRD577	BIX01294	4
iGMDRD506	Fedratinib	3
iGMDRD188	Piperlongumine	2
iGMDRD100	Zebularine	4
iGMDRD399	Selumetinib	2
iGMDRD356	PNU-74654	2
iGMDRD451	Serdemetan	2
iGMDRD64	Parbendazole	4
iGMDRD48	Dexamethasone	3
iGMDRD150	RITA	3
iGMDRD424	Tamatinib	3
iGMDRD341	Triacsin c	6
iGMDRD85	Ursolic acid	2
iGMDRD154	NSC23766	4
iGMDRD123	Isoevodiamine	5
iGMDRD158	NSC141540	6
iGMDRD289	Parthenolide	2
iGMDRD705	Nakiterpiosin	2
iGMDRD434	BMS-536924	2
iGMDRD269	Purmorphamine	2
iGMDRD286	Nsc 632839	1
iGMDRD300	Tozasertib	2
iGMDRD246	NPC26	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LYN

SITE

DATATYPES

CLASSFICATION

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