DDIT3
Summary: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA damage inducible transcript 3 | MIM:126337 | Ensembl:ENSG00000175197 | HGNC:HGNC:2726 | PA27193 | 12q13.3 |
GO terms in DDIT3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005770 | late endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032993 | protein-DNA complex |
| CC | ISS | GO:0035976 | transcription factor AP-1 complex |
| CC | IBA | GO:0036488 | CHOP-C/EBP complex |
| CC | ISS | GO:0036488 | CHOP-C/EBP complex |
| CC | TAS | GO:0036488 | CHOP-C/EBP complex |
| CC | IBA | GO:1990617 | CHOP-ATF4 complex |
| CC | IDA | GO:1990617 | CHOP-ATF4 complex |
| CC | IPI | GO:1990617 | CHOP-ATF4 complex |
| CC | IBA | GO:1990622 | CHOP-ATF3 complex |
| CC | IDA | GO:1990622 | CHOP-ATF3 complex |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001955 | blood vessel maturation |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0006983 | ER overload response |
| BP | IDA | GO:0006986 | response to unfolded protein |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IMP | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IDA | GO:0032792 | negative regulation of CREB transcription factor activity |
| BP | IGI | GO:0032792 | negative regulation of CREB transcription factor activity |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | TAS | GO:0036499 | PERK-mediated unfolded protein response |
| BP | TAS | GO:0036500 | ATF6-mediated unfolded protein response |
| BP | IEA | GO:0042594 | response to starvation |
| BP | IDA | GO:0042789 | mRNA transcription by RNA polymerase II |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IC | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | TAS | GO:0043620 | regulation of DNA-templated transcription in response to stress |
| BP | ISS | GO:0044324 | regulation of transcription involved in anterior/posterior axis specification |
| BP | IDA | GO:0045454 | cell redox homeostasis |
| BP | IEA | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IEA | GO:0045662 | negative regulation of myoblast differentiation |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | IMP | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IBA | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IDA | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IMP | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | TAS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | IEA | GO:0072655 | establishment of protein localization to mitochondrion |
| BP | ISS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IC | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | IDA | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| BP | IDA | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| BP | IGI | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| BP | IMP | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| BP | ISS | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| BP | IEA | GO:1990442 | intrinsic apoptotic signaling pathway in response to nitrosative stress |
| BP | IDA | GO:2000016 | negative regulation of determination of dorsal identity |
| MF | IDA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IC | GO:0003700 | DNA-binding transcription factor activity |
| MF | IGI | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008140 | cAMP response element binding protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0043522 | leucine zipper domain binding |
| MF | IC | GO:0044212 | transcription regulatory region DNA binding |
| MF | ISS | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | NAS | GO:0046982 | protein heterodimerization activity |
| MF | TAS | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: DDIT3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDIT3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| netpath | Pathway_RAGE | RAGE |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2655 | ATF6 (ATF6-alpha) activates chaperone genes |
| wikipathways | WP2753 | ATF4 activates genes |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP4211 | Transcriptional cascade regulating adipogenesis |
| reactome | R-HSA-380994 | ATF4 activates genes |
| reactome | R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones |
| reactome | R-HSA-381042 | PERK regulates gene expression |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD297 | Austocystin D | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDIT3
CLASSFICATION
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