ADGRB3
Summary: This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adhesion G protein-coupled receptor B3 | MIM:602684 | Ensembl:ENSG00000135298 | HGNC:HGNC:945 | PA25249 | 6q12-q13 |
Gene Categories:
G PROTEIN COUPLED RECEPTORGO terms in ADGRB3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | ISS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IPI | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043083 | synaptic cleft |
| CC | IEA | GO:0043083 | synaptic cleft |
| CC | IBA | GO:0098794 | postsynapse |
| CC | IEA | GO:0098794 | postsynapse |
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007520 | myoblast fusion |
| BP | IBA | GO:0016322 | neuron remodeling |
| BP | IEA | GO:0016322 | neuron remodeling |
| BP | IEA | GO:0016525 | negative regulation of angiogenesis |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0048814 | regulation of dendrite morphogenesis |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | IEA | GO:0061743 | motor learning |
| BP | IEA | GO:0099558 | maintenance of synapse structure |
Gene expression in normal tissue: ADGRB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRB3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD662 | JQ-1 | 7 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD435 | BI-2536 | 2 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD224 | Necrostatin-1 | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD670 | ML 210 | 4 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD380 | Pifithrin-alpha | 2 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRB3
CLASSFICATION
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