VAV1
Summary: This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vav guanine nucleotide exchange factor 1 | MIM:164875 | Ensembl:ENSG00000141968 | HGNC:HGNC:12657 | PA37280 | 19p13.3 |
Gene Categories:
KINASEGO terms in VAV1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | IGI | GO:0008361 | regulation of cell size |
| BP | IGI | GO:0008361 | regulation of cell size |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030217 | T cell differentiation |
| BP | IEA | GO:0030593 | neutrophil chemotaxis |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IGI | GO:0043087 | regulation of GTPase activity |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0072593 | reactive oxygen species metabolic process |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | EXP | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
Gene expression in normal tissue: VAV1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VAV1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | rac1_reg_pathway | Regulation of RAC1 activity |
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389359 | CD28 dependent Vav1 pathway |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5218920 | VEGFR2 mediated vascular permeability |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | nkcellspathway | ras-independent pathway in nk cell-mediated cytotoxicity |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | raspathway | ras signaling pathway |
| biocarta | rhopathway | rho cell motility signaling pathway |
| biocarta | tcrpathway | t cell receptor signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD505 | Pevonedistat | 10 |
| iGMDRD268 | Cerulenin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VAV1
CLASSFICATION
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