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IKBKE

Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinhibitor of nuclear factor kappa B kinase subunit epsilon OMIM IDMIM:605048 Ensembl IDEnsembl:ENSG00000263528 HGNC IDHGNC:HGNC:14552 PHARMGKB IDPA134962294 Map Location1q32.1

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE CLINICALLY ACTIONABLE

GO terms in IKBKE

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004704	NF-kappaB-inducing kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0008384	IkappaB kinase activity

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Gene expression in normal tissue: IKBKE

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IKBKE

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Database	Pathway ID	Pathway Des.
kegg	hsa04620	Toll-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04621	NOD-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04622	RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04623	Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegg	hsa04625	C-type lectin receptor signaling pathway - Homo sapiens (human)
kegg	hsa04657	IL-17 signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD494	Neopeltolide	3
iGMDRD427	ABT737	3
iGMDRD434	BMS-536924	3
iGMDRD150	RITA	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IKBKE

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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