CAMKK2
Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase kinase 2 | MIM:615002 | Ensembl:ENSG00000110931 | HGNC:HGNC:1470 | PA26052 | 12q24.31 |
GO terms in CAMKK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | TAS | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0019722 | calcium-mediated signaling |
| BP | TAS | GO:0034614 | cellular response to reactive oxygen species |
| BP | TAS | GO:0045859 | regulation of protein kinase activity |
| BP | TAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0061762 | CAMKK-AMPK signaling cascade |
| BP | IC | GO:1903599 | positive regulation of autophagy of mitochondrion |
| CC | IMP | GO:0005622 | intracellular |
| CC | TAS | GO:0005622 | intracellular |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0042995 | cell projection |
Gene expression in normal tissue: CAMKK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMKK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | cacampathway | ca-calmodulin-dependent protein kinase activation |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | pgc1apathway | regulation of pgc-1a |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_Ghrelin | Ghrelin |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD77 | Itraconazole | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMKK2
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