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PLK2

Summary: The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namepolo like kinase 2 OMIM IDMIM:607023 Ensembl IDEnsembl:ENSG00000145632 HGNC IDHGNC:HGNC:19699 PHARMGKB IDPA134940798 Map Location5q11.2

Gene Categories:

DRUGGABLE GENOME TUMOR SUPPRESSOR KINASE SERINE THREONINE KINASE CLINICALLY ACTIONABLE

GO terms in PLK2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IDA	GO:0043008	ATP-dependent protein binding
MF	IEA	GO:0044877	protein-containing complex binding

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Gene expression in normal tissue: PLK2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLK2

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes
reactome	R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD506	Fedratinib	3
iGMDRD188	Piperlongumine	2
iGMDRD414	MST-312	6
iGMDRD286	Nsc 632839	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLK2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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