PPP3CC
Summary: Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 3 catalytic subunit gamma | MIM:114107 | Ensembl:ENSG00000120910 | HGNC:HGNC:9316 | PA33680 | 8p21.3 |
Gene Categories:
PROTEIN PHOSPHATASEGO terms in PPP3CC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IBA | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| MF | IDA | GO:0033192 | calmodulin-dependent protein phosphatase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IDA | GO:0006470 | protein dephosphorylation |
| BP | IEA | GO:0007420 | brain development |
| BP | IDA | GO:0033173 | calcineurin-NFAT signaling cascade |
| BP | IBA | GO:0097720 | calcineurin-mediated signaling |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005955 | calcineurin complex |
Gene expression in normal tissue: PPP3CC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP3CC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| pid | bcr_5pathway | BCR signaling pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | calcineurinpathway | effects of calcineurin in keratinocyte differentiation |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gpcrpathway | signaling pathway from g-protein families |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | ndkdynaminpathway | endocytotic role of ndk phosphins and dynamin |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | nos1pathway | nitric oxide signaling pathway |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111447 | Activation of BAD and translocation to mitochondria |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-180024 | DARPP-32 events |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-5357801 | Programmed Cell Death |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD945 | ML214 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP3CC
CLASSFICATION
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