PPP3CC

Summary: Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameprotein phosphatase 3 catalytic subunit gamma
OMIM IDMIM:114107
Ensembl IDEnsembl:ENSG00000120910
HGNC IDHGNC:HGNC:9316
PHARMGKB IDPA33680
Map Location8p21.3

Gene Categories:

PROTEIN PHOSPHATASE

GO terms in PPP3CC


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0005516 calmodulin binding
MF IEA GO:0005516 calmodulin binding
MF IBA GO:0033192 calmodulin-dependent protein phosphatase activity
MF IDA GO:0033192 calmodulin-dependent protein phosphatase activity
MF IEA GO:0046872 metal ion binding
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Gene expression in normal tissue: PPP3CC

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined9Chromatin histone acetylation1

Pathways in PPP3CC


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Database
Pathway ID
Pathway Des.
wikipathways WP1541 Energy Metabolism
wikipathways WP2059 Alzheimers Disease
wikipathways WP2447 Amyotrophic lateral sclerosis (ALS)
wikipathways WP3414 Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathways WP35 G Protein Signaling Pathways
wikipathways WP382 MAPK Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD289 Parthenolide 1
iGMDRD150 RITA 2
iGMDRD105 Triptolide 3
iGMDRD434 BMS-536924 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPP3CC

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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