GPR183
Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor 183 | MIM:605741 | Ensembl:ENSG00000169508 | HGNC:HGNC:3128 | PA162390174 | 13q32.3 |
GO terms in GPR183
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0002250 | adaptive immune response |
| BP | IBA | GO:0002312 | B cell activation involved in immune response |
| BP | ISS | GO:0002313 | mature B cell differentiation involved in immune response |
| BP | ISS | GO:0002407 | dendritic cell chemotaxis |
| BP | TAS | GO:0006955 | immune response |
| BP | ISS | GO:0006959 | humoral immune response |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0010818 | T cell chemotaxis |
| BP | ISS | GO:0030316 | osteoclast differentiation |
| BP | IMP | GO:0030595 | leukocyte chemotaxis |
| BP | IDA | GO:0030890 | positive regulation of B cell proliferation |
| BP | ISS | GO:0036145 | dendritic cell homeostasis |
| BP | ISS | GO:0061470 | T follicular helper cell differentiation |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:2000458 | regulation of astrocyte chemotaxis |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IDA | GO:0004930 | G-protein coupled receptor activity |
| MF | IDA | GO:0008142 | oxysterol binding |
| MF | IMP | GO:0008142 | oxysterol binding |
Gene expression in normal tissue: GPR183
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPR183
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| wikipathways | WP117 | GPCRs, Other |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD329 | Merck60 | 9 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD150 | RITA | 7 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD144 | NSC95397 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPR183
CLASSFICATION
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