GPR183

Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameG protein-coupled receptor 183
OMIM IDMIM:605741
Ensembl IDEnsembl:ENSG00000169508
HGNC IDHGNC:HGNC:3128
PHARMGKB IDPA162390174
Map Location13q32.3

GO terms in GPR183


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0002250 adaptive immune response
BP IBA GO:0002312 B cell activation involved in immune response
BP ISS GO:0002313 mature B cell differentiation involved in immune response
BP ISS GO:0002407 dendritic cell chemotaxis
BP TAS GO:0006955 immune response
BP ISS GO:0006959 humoral immune response
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Gene expression in normal tissue: GPR183

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 23undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 20LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 21

Gene-drug pathway distribution

undefined16IGFR signaling1Cell cycle1Chromatin histone acetylation1Mitosis1Apoptosis regulation1

Pathways in GPR183


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-418594 G alpha (i) signalling events
reactome R-HSA-500792 GPCR ligand binding
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD871 BRD6368 4
iGMDRD286 Nsc 632839 4
iGMDRD872 BRD7137 2
iGMDRD577 BIX01294 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPR183

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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