GPR183


Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor 183MIM:605741Ensembl:ENSG00000169508HGNC:HGNC:3128PA16239017413q32.3

GO terms in GPR183


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0002250adaptive immune response
BPIBAGO:0002312B cell activation involved in immune response
BPISSGO:0002313mature B cell differentiation involved in immune response
BPISSGO:0002407dendritic cell chemotaxis
BPTASGO:0006955immune response
BPISSGO:0006959humoral immune response
BPIDAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPISSGO:0010818T cell chemotaxis
BPISSGO:0030316osteoclast differentiation
BPIMPGO:0030595leukocyte chemotaxis
BPIDAGO:0030890positive regulation of B cell proliferation
BPISSGO:0036145dendritic cell homeostasis
BPISSGO:0061470T follicular helper cell differentiation
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:2000458regulation of astrocyte chemotaxis
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
MFIBAGO:0004930G-protein coupled receptor activity
MFIDAGO:0004930G-protein coupled receptor activity
MFIDAGO:0008142oxysterol binding
MFIMPGO:0008142oxysterol binding

Gene expression in normal tissue: GPR183

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GPR183


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-500792GPCR ligand binding
wikipathwaysWP117GPCRs, Other

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD871BRD63684
iGMDRD286Nsc 6328394
iGMDRD872BRD71372
iGMDRD577BIX012944
iGMDRD329Merck609
iGMDRD300Tozasertib5
iGMDRD886Compound 1541A1
iGMDRD255SB2250022
iGMDRD289Parthenolide1
iGMDRD434BMS-5369242
iGMDRD782DC-45-A22
iGMDRD318PAC-11
iGMDRD351GW843682X4
iGMDRD61Kinetin riboside2
iGMDRD634SCHEMBL26080412
iGMDRD945ML2143
iGMDRD512nutlin 36
iGMDRD148Pifithrin-mu2
iGMDRD150RITA7
iGMDRD546BMS-7548073
iGMDRD144NSC953973

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPR183

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