MALT1


Summary: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:604860
PHARMGKB IDPA30568
Map Location18q21.32

GO terms in MALT1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0001650 fibrillar center
CC IDA GO:0005634 nucleus
CC IDA GO:0005730 nucleolus
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
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Gene expression in normal tissue: MALT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MALT1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
reactome R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
reactome R-HSA-1169091 Activation of NF-kappaB in B cells
reactome R-HSA-1169091 Activation of NF-kappaB in B cells
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1280218 Adaptive Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD77 Itraconazole 1
iGMDRD481 Dactolisib 5
iGMDRD192 CIL56 2
iGMDRD289 Parthenolide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MALT1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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