MALT1
Summary: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MALT1 paracaspase | MIM:604860 | Ensembl:ENSG00000172175 | HGNC:HGNC:6819 | PA30568 | 18q21.32 |
GO terms in MALT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0032449 | CBM complex |
| CC | NAS | GO:0032449 | CBM complex |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0001923 | B-1 B cell differentiation |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0002237 | response to molecule of bacterial origin |
| BP | IMP | GO:0002726 | positive regulation of T cell cytokine production |
| BP | IDA | GO:0006508 | proteolysis |
| BP | NAS | GO:0006952 | defense response |
| BP | IMP | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | IEA | GO:0009620 | response to fungus |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | NAS | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IMP | GO:0032743 | positive regulation of interleukin-2 production |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IEA | GO:0042098 | T cell proliferation |
| BP | IBA | GO:0042113 | B cell activation |
| BP | IDA | GO:0042981 | regulation of apoptotic process |
| BP | NAS | GO:0043066 | negative regulation of apoptotic process |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IBA | GO:0050852 | T cell receptor signaling pathway |
| BP | IDA | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IEA | GO:0050856 | regulation of T cell receptor signaling pathway |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051168 | nuclear export |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | ISS | GO:2000321 | positive regulation of T-helper 17 cell differentiation |
| MF | IEA | GO:0002020 | protease binding |
| MF | NAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | IMP | GO:0019209 | kinase activator activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043621 | protein self-association |
Gene expression in normal tissue: MALT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MALT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5660668 | CLEC7A/inflammasome pathway |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD481 | Dactolisib | 5 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD137 | Indisulam | 8 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 10 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD1008 | SR-II-138A | 4 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD193 | Fqi1 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MALT1
CLASSFICATION
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