ANGPTL4


Summary: This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
angiopoietin like 4MIM:605910Ensembl:ENSG00000167772HGNC:HGNC:16039PA2479719p13.2

GO terms in ANGPTL4


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0004857enzyme inhibitor activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
BPIEAGO:0001525angiogenesis
BPNASGO:0001666response to hypoxia
BPTASGO:0019216regulation of lipid metabolic process
BPIEAGO:0030154cell differentiation
BPIDAGO:0043066negative regulation of apoptotic process
BPTASGO:0045766positive regulation of angiogenesis
BPIDAGO:0051005negative regulation of lipoprotein lipase activity
BPIEAGO:0051260protein homooligomerization
BPISSGO:0070328triglyceride homeostasis
BPIEAGO:2000352negative regulation of endothelial cell apoptotic process
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCHDAGO:0072562blood microparticle

Gene expression in normal tissue: ANGPTL4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ANGPTL4


DatabasePathway IDPathway Des.
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04979Cholesterol metabolism - Homo sapiens (human)
wikipathwaysWP2751Transcriptional regulation of white adipocyte differentiation
wikipathwaysWP2797Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
wikipathwaysWP2880Glucocorticoid Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3942PPAR signaling pathway
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8963889Assembly of active LPL and LIPC lipase complexes
reactomeR-HSA-8963899Plasma lipoprotein remodeling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD147Prima-13
iGMDRD394BX-7951
iGMDRD577BIX012943
iGMDRD562Navitoclax3
iGMDRD882CIL413
iGMDRD885Compound 1102
iGMDRD30917AAG1
iGMDRD187BRD98763
iGMDRD870BRD636101
iGMDRD781Sirolimus3
iGMDRD434BMS-5369243
iGMDRD425ERASTIN2
iGMDRD84Lovastatin acid3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ANGPTL4

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