ANGPTL4
Summary: This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| angiopoietin like 4 | MIM:605910 | Ensembl:ENSG00000167772 | HGNC:HGNC:16039 | PA24797 | 19p13.2 |
GO terms in ANGPTL4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004857 | enzyme inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | NAS | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0045766 | positive regulation of angiogenesis |
| BP | IDA | GO:0051005 | negative regulation of lipoprotein lipase activity |
| BP | IEA | GO:0051260 | protein homooligomerization |
| BP | ISS | GO:0070328 | triglyceride homeostasis |
| BP | IEA | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0072562 | blood microparticle |
Gene expression in normal tissue: ANGPTL4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ANGPTL4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| wikipathways | WP2751 | Transcriptional regulation of white adipocyte differentiation |
| wikipathways | WP2797 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3942 | PPAR signaling pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes |
| reactome | R-HSA-8963899 | Plasma lipoprotein remodeling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ANGPTL4
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