PXK


Summary: This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PX domain containing serine/threonine kinase likeMIM:611450Ensembl:ENSG00000168297HGNC:HGNC:23326PA1348994963p14.3

GO terms in PXK


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0006468protein phosphorylation
BPIMPGO:0006954inflammatory response
BPIBAGO:0032780negative regulation of ATPase activity
BPIBAGO:0042391regulation of membrane potential
BPIBAGO:0043271negative regulation of ion transport
BPISSGO:0050804modulation of chemical synaptic transmission
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIDAGO:0005815microtubule organizing center
CCIDAGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCISSGO:0005886plasma membrane
CCIEAGO:0032991protein-containing complex
MFNASGO:0000166nucleotide binding
MFIEAGO:0003779actin binding
MFNASGO:0004672protein kinase activity
MFNASGO:0005524ATP binding
MFIEAGO:0035091phosphatidylinositol binding

Gene expression in normal tissue: PXK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PXK


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD779PRL-3 Inhibitor I2
iGMDRD427ABT7371
iGMDRD151CHM-12
iGMDRD433Lexibulin4
iGMDRD599Salermide4
iGMDRD446LY 21832403
iGMDRD639YK 4-2792
iGMDRD61Kinetin riboside2
iGMDRD193Fqi13
iGMDRD207Capsaicin1
iGMDRD318PAC-12
iGMDRD480KU00606482
iGMDRD138PX 123
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine3
iGMDRD356PNU-746541
iGMDRD188Piperlongumine3
iGMDRD888Compound 443
iGMDRD562Navitoclax1
iGMDRD398Sepantronium2
iGMDRD79Gemcitabine4
iGMDRD84Lovastatin acid2
iGMDRD901ELCPK2
iGMDRD211(1S,3R)-RSL32
iGMDRD177Teniposide4
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD154NSC237662
iGMDRD57Chloropentafluorobenzene4
iGMDRD237ABT-7512
iGMDRD705Nakiterpiosin3
iGMDRD6AM-5805
iGMDRD105Triptolide3
iGMDRD481Dactolisib1
iGMDRD213SMR0000686503
iGMDRD271Brefeldin A2
iGMDRD158NSC1415404
iGMDRD82Quiflapon4
iGMDRD286Nsc 6328393
iGMDRD871BRD63686
iGMDRD329Merck604

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PXK

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