PXK
Summary: This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PX domain containing serine/threonine kinase like | MIM:611450 | Ensembl:ENSG00000168297 | HGNC:HGNC:23326 | PA134899496 | 3p14.3 |
GO terms in PXK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006954 | inflammatory response |
| BP | IBA | GO:0032780 | negative regulation of ATPase activity |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0043271 | negative regulation of ion transport |
| BP | ISS | GO:0050804 | modulation of chemical synaptic transmission |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0032991 | protein-containing complex |
| MF | NAS | GO:0000166 | nucleotide binding |
| MF | IEA | GO:0003779 | actin binding |
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | NAS | GO:0005524 | ATP binding |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
Gene expression in normal tissue: PXK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PXK
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD480 | KU0060648 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 4 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD329 | Merck60 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PXK
CLASSFICATION
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