CYLD

Summary: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameCYLD lysine 63 deubiquitinase
OMIM IDMIM:605018
Ensembl IDEnsembl:ENSG00000083799
HGNC IDHGNC:HGNC:2584
PHARMGKB IDPA27084
Map Location16q12.1

GO terms in CYLD


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006511 ubiquitin-dependent protein catabolic process
BP IEA GO:0007049 cell cycle
BP IBA GO:0007346 regulation of mitotic cell cycle
BP IMP GO:0007346 regulation of mitotic cell cycle
BP IDA GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
BP TAS GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
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Gene expression in normal tissue: CYLD

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 54BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 14LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6

Gene-drug pathway distribution

undefined23Apoptosis regulation1Other, kinases1Chromatin histone acetylation1Cell cycle1Purine metabolism1Longevity regulating pathway1

Pathways in CYLD


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-168638 NOD1/2 Signaling Pathway
reactome R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactome R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 2
iGMDRD79 Gemcitabine 4
iGMDRD494 Neopeltolide 2
iGMDRD599 Salermide 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYLD

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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