CYLD
Summary: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CYLD lysine 63 deubiquitinase | MIM:605018 | Ensembl:ENSG00000083799 | HGNC:HGNC:2584 | PA27084 | 16q12.1 |
GO terms in CYLD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | IDA | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IBA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0032480 | negative regulation of type I interferon production |
| BP | IEA | GO:0043369 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment |
| BP | IEA | GO:0043393 | regulation of protein binding |
| BP | IDA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045577 | regulation of B cell differentiation |
| BP | IEA | GO:0045581 | negative regulation of T cell differentiation |
| BP | IEA | GO:0045582 | positive regulation of T cell differentiation |
| BP | IEA | GO:0048872 | homeostasis of number of cells |
| BP | IEA | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| BP | IBA | GO:0070266 | necroptotic process |
| BP | TAS | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IMP | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | IBA | GO:0070536 | protein K63-linked deubiquitination |
| BP | IDA | GO:0070536 | protein K63-linked deubiquitination |
| BP | IEA | GO:0071108 | protein K48-linked deubiquitination |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:1901026 | ripoptosome assembly involved in necroptotic process |
| BP | IDA | GO:1901223 | negative regulation of NIK/NF-kappaB signaling |
| BP | ISS | GO:1902017 | regulation of cilium assembly |
| BP | IEA | GO:1903829 | positive regulation of cellular protein localization |
| BP | IDA | GO:1990108 | protein linear deubiquitination |
| BP | IBA | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| BP | IBA | GO:2001242 | regulation of intrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005819 | spindle |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005881 | cytoplasmic microtubule |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | ISS | GO:0036064 | ciliary basal body |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0097542 | ciliary tip |
| MF | IBA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| MF | IBA | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | IDA | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | TAS | GO:0061578 | Lys63-specific deubiquitinase activity |
| MF | IPI | GO:0070064 | proline-rich region binding |
| MF | IEA | GO:1990380 | Lys48-specific deubiquitinase activity |
Gene expression in normal tissue: CYLD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYLD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5357786 | TNFR1-induced proapoptotic signaling |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_RANKL | RANKL |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD886 | Compound 1541A | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD100 | Zebularine | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYLD
CLASSFICATION
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