KTN1

Summary: This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namekinectin 1
OMIM IDMIM:600381
Ensembl IDEnsembl:ENSG00000126777
HGNC IDHGNC:HGNC:6467
PHARMGKB IDPA30256
Map Location14q22.3

GO terms in KTN1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IPI GO:0005515 protein binding
MF HDA GO:0045296 cadherin binding
BP IEA GO:0007018 microtubule-based movement
BP TAS GO:0043687 post-translational protein modification
BP TAS GO:0044267 cellular protein metabolic process
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Gene expression in normal tissue: KTN1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 21undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6

Gene-drug pathway distribution

undefined13Longevity regulating pathway1p53 pathway1Apoptosis regulation1PI3K/MTOR signaling1

Pathways in KTN1


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Database
Pathway ID
Pathway Des.
wikipathways WP2880 Glucocorticoid Receptor Pathway
wikipathways WP2882 Nuclear Receptors Meta-Pathway
netpath Pathway_TNFalpha TNFalpha
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-195258 RHO GTPase Effectors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD513 BML-259 1
iGMDRD187 BRD9876 1
iGMDRD481 Dactolisib 2
iGMDRD226 ML006 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KTN1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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