IRAK3
Summary: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 1 receptor associated kinase 3 | MIM:604459 | Ensembl:ENSG00000090376 | HGNC:HGNC:17020 | PA38431 | 12q14.3 |
GO terms in IRAK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005886 | plasma membrane |
| BP | IC | GO:0001960 | negative regulation of cytokine-mediated signaling pathway |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IC | GO:0009615 | response to virus |
| BP | ISS | GO:0010933 | positive regulation of macrophage tolerance induction |
| BP | ISS | GO:0010936 | negative regulation of macrophage cytokine production |
| BP | IBA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | ISS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0032494 | response to peptidoglycan |
| BP | ISS | GO:0032496 | response to lipopolysaccharide |
| BP | IMP | GO:0032695 | negative regulation of interleukin-12 production |
| BP | ISS | GO:0032695 | negative regulation of interleukin-12 production |
| BP | IMP | GO:0032715 | negative regulation of interleukin-6 production |
| BP | ISS | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IMP | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | ISS | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0042177 | negative regulation of protein catabolic process |
| BP | IMP | GO:0043242 | negative regulation of protein complex disassembly |
| BP | ISS | GO:0043244 | regulation of protein complex disassembly |
| BP | ISS | GO:0043330 | response to exogenous dsRNA |
| BP | IBA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IMP | GO:0043407 | negative regulation of MAP kinase activity |
| BP | ISS | GO:0045824 | negative regulation of innate immune response |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: IRAK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRAK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | il1rpathway | signal transduction through il1r |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP195 | IL-1 signaling pathway |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| pid | il1pathway | IL1-mediated signaling events |
| netpath | Pathway_IL1 | IL1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD77 | Itraconazole | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRAK3
CLASSFICATION
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