IRAK3

Summary: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameinterleukin 1 receptor associated kinase 3
OMIM IDMIM:604459
Ensembl IDEnsembl:ENSG00000090376
HGNC IDHGNC:HGNC:17020
PHARMGKB IDPA38431
Map Location12q14.3

GO terms in IRAK3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005737 cytoplasm
CC IBA GO:0005886 plasma membrane
BP IC GO:0001960 negative regulation of cytokine-mediated signaling pathway
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Gene expression in normal tissue: IRAK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined24Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Mitosis1Apoptosis regulation1Cell cycle1Protein stability and degradation1Other, kinases1

Pathways in IRAK3


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Database
Pathway ID
Pathway Des.
biocarta il1rpathway signal transduction through il1r
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
reactome R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
reactome R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
reactome R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 3
iGMDRD341 Triacsin c 3
iGMDRD193 Fqi1 6
iGMDRD61 Kinetin riboside 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRAK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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