PREX2


Summary: The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016].

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Name
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Ensembl ID
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Gene Categories:

KINASE

GO terms in PREX2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0005096 GTPase activator activity
MF IBA GO:0030676 Rac guanyl-nucleotide exchange factor activity
MF IDA GO:0030676 Rac guanyl-nucleotide exchange factor activity
BP IBA GO:0006469 negative regulation of protein kinase activity
BP IBA GO:0007186 G-protein coupled receptor signaling pathway
BP IDA GO:0007186 G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: PREX2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined42Apoptosis regulation3Cell cycle2ERK MAPK signaling2Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Purine metabolism1Ferroptosis1Proteasome1p53 pathway1

Pathways in PREX2


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Database
Pathway ID
Pathway Des.
pid rac1_reg_pathway Regulation of RAC1 activity
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-6807070 PTEN Regulation
reactome R-HSA-8948751 Regulation of PTEN stability and activity
reactome R-HSA-9006925 Intracellular signaling by second messengers
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 6
iGMDRD201 SKI II 3
iGMDRD639 YK 4-279 2
iGMDRD152 179324-69-7 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PREX2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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