PREX2
Summary: The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:612139 Ensembl IDEnsembl:ENSG00000046889 HGNC IDHGNC:HGNC:22950 PHARMGKB IDPA164725103 Map Location8q13.2 |
Gene Categories:
KINASEGO terms in PREX2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0005096 | GTPase activator activity |
MF | IBA | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
MF | IDA | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
BP | IBA | GO:0006469 | negative regulation of protein kinase activity |
BP | IBA | GO:0007186 | G-protein coupled receptor signaling pathway |
BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
Gene expression in normal tissue: PREX2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PREX2
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | rac1_reg_pathway | Regulation of RAC1 activity |
reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-6807070 | PTEN Regulation |
reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PREX2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |