ABL2

Summary: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameABL proto-oncogene 2, non-receptor tyrosine kinase
OMIM IDMIM:164690
Ensembl IDEnsembl:ENSG00000143322
HGNC IDHGNC:HGNC:77
PHARMGKB IDPA24414
Map Location1q25.2

GO terms in ABL2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005829 cytosol
CC TAS GO:0015629 actin cytoskeleton
CC IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
BP TAS GO:0006464 cellular protein modification process
BP IEA GO:0007155 cell adhesion
BP TAS GO:0007165 signal transduction
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Gene expression in normal tissue: ABL2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 53undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 2BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 5

Gene-drug pathway distribution

undefined21Proteasome1Purine metabolism1Apoptosis regulation1Biosynthesis of secondary metabolites1

Pathways in ABL2


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Database
Pathway ID
Pathway Des.
biocarta actinypathway y branching of actin filaments
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-376176 Signaling by ROBO receptors
reactome R-HSA-376176 Signaling by ROBO receptors
reactome R-HSA-422475 Axon guidance
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 2
iGMDRD434 BMS-536924 2
iGMDRD6 AM-580 6
iGMDRD52 Rotenone 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABL2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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