ABL2
Summary: This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ABL proto-oncogene 2, non-receptor tyrosine kinase | MIM:164690 | Ensembl:ENSG00000143322 | HGNC:HGNC:77 | PA24414 | 1q25.2 |
GO terms in ABL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IMP | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0010506 | regulation of autophagy |
| BP | IMP | GO:0010863 | positive regulation of phospholipase C activity |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0030100 | regulation of endocytosis |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030155 | regulation of cell adhesion |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IDA | GO:0051353 | positive regulation of oxidoreductase activity |
| BP | IMP | GO:0071300 | cellular response to retinoic acid |
| BP | TAS | GO:2000145 | regulation of cell motility |
| BP | TAS | GO:2000249 | regulation of actin cytoskeleton reorganization |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | TAS | GO:0003785 | actin monomer binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0030145 | manganese ion binding |
| MF | TAS | GO:0051015 | actin filament binding |
Gene expression in normal tissue: ABL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | actinypathway | y branching of actin filaments |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428890 | Role of ABL in ROBO-SLIT signaling |
| reactome | R-HSA-428890 | Role of ABL in ROBO-SLIT signaling |
| wikipathways | WP4223 | Ras Signaling |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD6 | AM-580 | 6 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD79 | Gemcitabine | 5 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD375 | GW-405833 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABL2
CLASSFICATION
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