GSDME


Summary: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
gasdermin EMIM:608798Ensembl:ENSG00000105928HGNC:HGNC:2810PA272817p15.3

GO terms in GSDME


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007605sensory perception of sound
BPIMPGO:0008219cell death
BPIDAGO:0008285negative regulation of cell proliferation
BPIMPGO:0043410positive regulation of MAPK cascade
BPIEAGO:0060113inner ear receptor cell differentiation
BPIDAGO:0070265necrotic cell death
BPIDAGO:0070269pyroptosis
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIDAGO:0098586cellular response to virus
BPIDAGO:2001244positive regulation of intrinsic apoptotic signaling pathway
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0016020membrane
MFIDAGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIDAGO:1901612cardiolipin binding

Gene expression in normal tissue: GSDME

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GSDME


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD781Sirolimus5
iGMDRD889Compound 7d-cis4
iGMDRD126Tipifarnib3
iGMDRD151CHM-12
iGMDRD634SCHEMBL26080413
iGMDRD193Fqi12
iGMDRD446LY 21832403
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD255SB2250022
iGMDRD260FQI-21
iGMDRD138PX 125
iGMDRD690PRIMA-1MET5
iGMDRD64Parbendazole2
iGMDRD562Navitoclax2
iGMDRD188Piperlongumine2
iGMDRD399Selumetinib5
iGMDRD79Gemcitabine2
iGMDRD532Olaparib2
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A5
iGMDRD901ELCPK3
iGMDRD211(1S,3R)-RSL32
iGMDRD123Isoevodiamine3
iGMDRD137Indisulam3
iGMDRD202Curcumin5
iGMDRD158NSC1415404
iGMDRD300Tozasertib3
iGMDRD147Prima-12
iGMDRD329Merck603
iGMDRD871BRD63685
iGMDRD286Nsc 6328395
iGMDRD872BRD71372

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSDME

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