GSDME
Summary: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gasdermin E | MIM:608798 | Ensembl:ENSG00000105928 | HGNC:HGNC:2810 | PA27281 | 7p15.3 |
GO terms in GSDME
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007605 | sensory perception of sound |
| BP | IMP | GO:0008219 | cell death |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0060113 | inner ear receptor cell differentiation |
| BP | IDA | GO:0070265 | necrotic cell death |
| BP | IDA | GO:0070269 | pyroptosis |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IDA | GO:0098586 | cellular response to virus |
| BP | IDA | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016020 | membrane |
| MF | IDA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IDA | GO:1901612 | cardiolipin binding |
Gene expression in normal tissue: GSDME
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSDME
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD690 | PRIMA-1MET | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 5 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 5 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD872 | BRD7137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSDME
CLASSFICATION
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