GSDME

Summary: Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namegasdermin E
OMIM IDMIM:608798
Ensembl IDEnsembl:ENSG00000105928
HGNC IDHGNC:HGNC:2810
PHARMGKB IDPA27281
Map Location7p15.3

GO terms in GSDME


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0007605 sensory perception of sound
BP IMP GO:0008219 cell death
BP IDA GO:0008285 negative regulation of cell proliferation
BP IMP GO:0043410 positive regulation of MAPK cascade
BP IEA GO:0060113 inner ear receptor cell differentiation
BP IDA GO:0070265 necrotic cell death
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Gene expression in normal tissue: GSDME

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GSDME


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 5
iGMDRD889 Compound 7d-cis 4
iGMDRD126 Tipifarnib 3
iGMDRD151 CHM-1 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSDME

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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