NEK4
Summary: The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 4 | MIM:601959 | Ensembl:ENSG00000114904 | HGNC:HGNC:11399 | PA31548 | 3p21.1 |
GO terms in NEK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000278 | mitotic cell cycle |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:1900062 | regulation of replicative cell aging |
| BP | IMP | GO:2000772 | regulation of cellular senescence |
| BP | IMP | GO:2001020 | regulation of response to DNA damage stimulus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0035253 | ciliary rootlet |
| CC | IEA | GO:0035869 | ciliary transition zone |
| CC | IEA | GO:0036064 | ciliary basal body |
| CC | IEA | GO:0097014 | ciliary plasm |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0030145 | manganese ion binding |
Gene expression in normal tissue: NEK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK4
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD484 | Pluripotin | 5 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD330 | BRD4132 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK4
CLASSFICATION
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