NEK4

Summary: The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameNIMA related kinase 4
OMIM IDMIM:601959
Ensembl IDEnsembl:ENSG00000114904
HGNC IDHGNC:HGNC:11399
PHARMGKB IDPA31548
Map Location3p21.1

GO terms in NEK4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0000278 mitotic cell cycle
BP ISS GO:0006468 protein phosphorylation
BP IMP GO:0006974 cellular response to DNA damage stimulus
BP IBA GO:0007346 regulation of mitotic cell cycle
BP IBA GO:0023014 signal transduction by protein phosphorylation
BP IBA GO:0032147 activation of protein kinase activity
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Gene expression in normal tissue: NEK4

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6

Gene-drug pathway distribution

undefined16Longevity regulating pathway1Ferroptosis1Apoptosis regulation1p53 pathway1DNA replication1

Pathways in NEK4


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD60 Quinoclamine 8
iGMDRD268 Cerulenin 2
iGMDRD451 Serdemetan 2
iGMDRD286 Nsc 632839 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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