KAT7
Summary: The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine acetyltransferase 7 | MIM:609880 | Ensembl:ENSG00000136504 | HGNC:HGNC:17016 | PA134886407 | 17q21.33 |
Gene Categories:
HISTONE MODIFICATIONGO terms in KAT7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IMP | GO:0003688 | DNA replication origin binding |
| MF | IBA | GO:0004402 | histone acetyltransferase activity |
| MF | IEA | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0010485 | H4 histone acetyltransferase activity |
| MF | IBA | GO:0042393 | histone binding |
| MF | IMP | GO:0044212 | transcription regulatory region DNA binding |
| BP | IDA | GO:0006260 | DNA replication |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0031098 | stress-activated protein kinase signaling cascade |
| BP | IBA | GO:0043966 | histone H3 acetylation |
| BP | IDA | GO:0043966 | histone H3 acetylation |
| BP | IDA | GO:0043981 | histone H4-K5 acetylation |
| BP | IDA | GO:0043982 | histone H4-K8 acetylation |
| BP | IDA | GO:0043983 | histone H4-K12 acetylation |
| BP | IDA | GO:0043984 | histone H4-K16 acetylation |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0072708 | response to sorbitol |
| BP | IMP | GO:0072710 | response to hydroxyurea |
| BP | IMP | GO:0072716 | response to actinomycin D |
| BP | IMP | GO:0072720 | response to dithiothreitol |
| BP | IMP | GO:0072739 | response to anisomycin |
| BP | IMP | GO:0090240 | positive regulation of histone H4 acetylation |
| BP | IDA | GO:1900182 | positive regulation of protein localization to nucleus |
| CC | IBA | GO:0000123 | histone acetyltransferase complex |
| CC | IDA | GO:0000123 | histone acetyltransferase complex |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex |
Gene expression in normal tissue: KAT7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KAT7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP138 | Androgen receptor signaling pathway |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KAT7
CLASSFICATION
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