RAD21
Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAD21 cohesin complex component | MIM:606462 | Ensembl:ENSG00000164754 | HGNC:HGNC:9811 | PA34170 | 8q24.11 |
GO terms in RAD21
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| CC | TAS | GO:0000775 | chromosome, centromeric region |
| CC | IEA | GO:0000785 | chromatin |
| CC | IBA | GO:0000798 | nuclear cohesin complex |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005694 | chromosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0008278 | cohesin complex |
| CC | TAS | GO:0008278 | cohesin complex |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016363 | nuclear matrix |
| CC | IBA | GO:0030893 | meiotic cohesin complex |
| BP | IBA | GO:0006302 | double-strand break repair |
| BP | TAS | GO:0006302 | double-strand break repair |
| BP | TAS | GO:0006310 | DNA recombination |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007059 | chromosome segregation |
| BP | IBA | GO:0007062 | sister chromatid cohesion |
| BP | TAS | GO:0007131 | reciprocal meiotic recombination |
| BP | IEA | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0045841 | negative regulation of mitotic metaphase/anaphase transition |
| BP | IMP | GO:0045876 | positive regulation of sister chromatid cohesion |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0071168 | protein localization to chromatin |
Gene expression in normal tissue: RAD21
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAD21
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4240 | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| reactome | R-HSA-1221632 | Meiotic synapsis |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2468052 | Establishment of Sister Chromatid Cohesion |
| reactome | R-HSA-2470946 | Cohesin Loading onto Chromatin |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68884 | Mitotic Telophase/Cytokinesis |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD318 | PAC-1 | 9 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD453 | GW2580 | 1 |
| iGMDRD200 | STF62247 | 1 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD1034 | WZ3105 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD163 | all trans Retinoic Acid | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD130 | Enzastaurin | 1 |
| iGMDRD945 | ML214 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAD21
CLASSFICATION
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