RASA3

Summary: This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRAS p21 protein activator 3
OMIM IDMIM:605182
Ensembl IDEnsembl:ENSG00000185989
HGNC IDHGNC:HGNC:20331
PHARMGKB IDPA134905447
Map Location13q34

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in RASA3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0000165 MAPK cascade
BP TAS GO:0007165 signal transduction
BP IEA GO:0043547 positive regulation of GTPase activity
BP IEA GO:0051209 release of sequestered calcium ion into cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane
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Gene expression in normal tissue: RASA3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 49undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 76undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 12BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3

Gene-drug pathway distribution

Pathways in RASA3


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Database
Pathway ID
Pathway Des.
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
netpath Pathway_TNFalpha TNFalpha
wikipathways WP422 MAPK Cascade
wikipathways WP4223 Ras Signaling
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD126 Tipifarnib 4
iGMDRD484 Pluripotin 6
iGMDRD144 NSC95397 4
iGMDRD427 ABT737 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RASA3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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