RASA3


Summary: This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAS p21 protein activator 3MIM:605182Ensembl:ENSG00000185989HGNC:HGNC:20331PA13490544713q34

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in RASA3


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPTASGO:0007165signal transduction
BPIEAGO:0043547positive regulation of GTPase activity
BPIEAGO:0051209release of sequestered calcium ion into cytosol
CCTASGO:0005829cytosol
CCIDAGO:0031235intrinsic component of the cytoplasmic side of the plasma membrane
MFIDAGO:0015278calcium-release channel activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: RASA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RASA3


DatabasePathway IDPathway Des.
kegghsa04014Ras signaling pathway - Homo sapiens (human)
netpathPathway_TNFalphaTNFalpha
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4223Ras Signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-5658442Regulation of RAS by GAPs
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802957Oncogenic MAPK signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib4
iGMDRD484Pluripotin6
iGMDRD144NSC953974
iGMDRD427ABT7373
iGMDRD152179324-69-73
iGMDRD446LY 21832404
iGMDRD297Austocystin D5
iGMDRD280CYTOCHALASIN B9
iGMDRD255SB2250023
iGMDRD138PX 124
iGMDRD870BRD636102
iGMDRD187BRD98763
iGMDRD100Zebularine3
iGMDRD188Piperlongumine4
iGMDRD887Compound 23 citrate4
iGMDRD23Gossypol3
iGMDRD84Lovastatin acid2
iGMDRD701NVP-AUY9221
iGMDRD116CD4375
iGMDRD57Chloropentafluorobenzene3
iGMDRD945ML2142
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine4
iGMDRD103SN-386
iGMDRD251ML1623
iGMDRD121GMX17782
iGMDRD77Itraconazole4
iGMDRD289Parthenolide2
iGMDRD705Nakiterpiosin5
iGMDRD434BMS-5369242
iGMDRD329Merck602
iGMDRD414MST-3129
iGMDRD871BRD63688
iGMDRD286Nsc 6328399
iGMDRD322FK 8663
iGMDRD505Pevonedistat2
iGMDRD886Compound 1541A3
iGMDRD246NPC262
iGMDRD263AACOCF32

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RASA3

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