RASA3
Summary: This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAS p21 protein activator 3 | MIM:605182 | Ensembl:ENSG00000185989 | HGNC:HGNC:20331 | PA134905447 | 13q34 |
GO terms in RASA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0051209 | release of sequestered calcium ion into cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane |
| MF | IDA | GO:0015278 | calcium-release channel activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: RASA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RASA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP4223 | Ras Signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5658442 | Regulation of RAS by GAPs |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD414 | MST-312 | 9 |
| iGMDRD871 | BRD6368 | 8 |
| iGMDRD286 | Nsc 632839 | 9 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD263 | AACOCF3 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RASA3
CLASSFICATION
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