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PSMA4

Summary: This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameproteasome subunit alpha 4 OMIM IDMIM:176846 Ensembl IDEnsembl:ENSG00000041357 HGNC IDHGNC:HGNC:9533 PHARMGKB IDPA33878 Map Location15q25.1

Gene Categories:

TUMOR SUPPRESSOR PROTEASE DRUGGABLE GENOME

GO terms in PSMA4

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0004175	endopeptidase activity
MF	IEA	GO:0004298	threonine-type endopeptidase activity
MF	IPI	GO:0005515	protein binding
BP	IEA	GO:0006511	ubiquitin-dependent protein catabolic process
BP	IBA	GO:0010498	proteasomal protein catabolic process
BP	IBA	GO:0010499	proteasomal ubiquitin-independent protein catabolic process

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Gene expression in normal tissue: PSMA4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PSMA4

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Database	Pathway ID	Pathway Des.
kegg	hsa03050	Proteasome - Homo sapiens (human)
wikipathways	WP183	Proteasome Degradation
wikipathways	WP410	Exercise-induced Circadian Regulation
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)
reactome	R-HSA-1169091	Activation of NF-kappaB in B cells

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD870	BRD63610	4
iGMDRD187	BRD9876	3
iGMDRD781	Sirolimus	6
iGMDRD885	Compound 110	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PSMA4

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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