PPARGC1A


Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PPARG coactivator 1 alphaMIM:604517Ensembl:ENSG00000109819HGNC:HGNC:9237PA335584p15.2

GO terms in PPARGC1A


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0003677DNA binding
MFTASGO:0003677DNA binding
MFTASGO:0003712transcription coregulator activity
MFIDAGO:0003713transcription coactivator activity
MFTASGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFTASGO:0008134transcription factor binding
MFIPIGO:0016922nuclear receptor binding
MFIEAGO:0030331estrogen receptor binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0030374nuclear receptor transcription coactivator activity
MFISSGO:0031490chromatin DNA binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIEAGO:0042975peroxisome proliferator activated receptor binding
MFIEAGO:0043014alpha-tubulin binding
MFIDAGO:0043565sequence-specific DNA binding
MFNASGO:0050681androgen receptor binding
MFIEAGO:1990841promoter-specific chromatin binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCTASGO:0005665DNA-directed RNA polymerase II, core complex
CCIEAGO:0005719nuclear euchromatin
CCIEAGO:0016605PML body
CCIEAGO:0022626cytosolic ribosome
CCIEAGO:0043025neuronal cell body
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIEAGO:0097440apical dendrite
CCIEAGO:1990843subsarcolemmal mitochondrion
CCIEAGO:1990844interfibrillar mitochondrion
BPIEAGO:0000302response to reactive oxygen species
BPIEAGO:0000422autophagy of mitochondrion
BPTASGO:0001659temperature homeostasis
BPNASGO:0001678cellular glucose homeostasis
BPIEAGO:0001933negative regulation of protein phosphorylation
BPIEAGO:0002021response to dietary excess
BPIEAGO:0002931response to ischemia
BPIEAGO:0006012galactose metabolic process
BPNASGO:0006094gluconeogenesis
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPTASGO:0006397mRNA processing
BPNASGO:0007005mitochondrion organization
BPTASGO:0007005mitochondrion organization
BPIEAGO:0007568aging
BPTASGO:0007586digestion
BPTASGO:0007623circadian rhythm
BPIEAGO:0008209androgen metabolic process
BPTASGO:0008380RNA splicing
BPIEAGO:0009409response to cold
BPIMPGO:0010822positive regulation of mitochondrion organization
BPISSGO:0010822positive regulation of mitochondrion organization
BPIEAGO:0014732skeletal muscle atrophy
BPISSGO:0014850response to muscle activity
BPIEAGO:0014878response to electrical stimulus involved in regulation of muscle adaptation
BPIEAGO:0014912negative regulation of smooth muscle cell migration
BPNASGO:0019395fatty acid oxidation
BPIEAGO:0021549cerebellum development
BPISSGO:0022904respiratory electron transport chain
BPNASGO:0030521androgen receptor signaling pathway
BPIEAGO:0030900forebrain development
BPISSGO:0032922circadian regulation of gene expression
BPISSGO:0034599cellular response to oxidative stress
BPTASGO:0035066positive regulation of histone acetylation
BPIEAGO:0035865cellular response to potassium ion
BPNASGO:0042594response to starvation
BPISSGO:0042752regulation of circadian rhythm
BPIEAGO:0043201response to leucine
BPISSGO:0043524negative regulation of neuron apoptotic process
BPTASGO:0045333cellular respiration
BPTASGO:0045722positive regulation of gluconeogenesis
BPIEAGO:0045820negative regulation of glycolytic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0046321positive regulation of fatty acid oxidation
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPIEAGO:0048662negative regulation of smooth muscle cell proliferation
BPTASGO:0050821protein stabilization
BPTASGO:0050873brown fat cell differentiation
BPIBAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0051552flavone metabolic process
BPIEAGO:0060612adipose tissue development
BPTASGO:0065003protein-containing complex assembly
BPIEAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:0071250cellular response to nitrite
BPIEAGO:0071313cellular response to caffeine
BPIEAGO:0071332cellular response to fructose stimulus
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0071354cellular response to interleukin-6
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071372cellular response to follicle-stimulating hormone stimulus
BPIEAGO:0071392cellular response to estradiol stimulus
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:0071560cellular response to transforming growth factor beta stimulus
BPIEAGO:0071871response to epinephrine
BPIEAGO:0071873response to norepinephrine
BPIEAGO:0090258negative regulation of mitochondrial fission
BPISSGO:0097009energy homeostasis
BPIEAGO:0097067cellular response to thyroid hormone stimulus
BPIGIGO:1901215negative regulation of neuron death
BPIEAGO:1901558response to metformin
BPIEAGO:1901857positive regulation of cellular respiration
BPIEAGO:1901860positive regulation of mitochondrial DNA metabolic process
BPIEAGO:1901863positive regulation of muscle tissue development
BPIEAGO:1904635positive regulation of glomerular visceral epithelial cell apoptotic process
BPIEAGO:1904637cellular response to ionomycin
BPIEAGO:1904639cellular response to resveratrol
BPIEAGO:1904640response to methionine
BPIEAGO:1990845adaptive thermogenesis
BPIEAGO:2000184positive regulation of progesterone biosynthetic process
BPIEAGO:2000272negative regulation of signaling receptor activity
BPIEAGO:2000310regulation of NMDA receptor activity
BPISSGO:2001171positive regulation of ATP biosynthetic process

Gene expression in normal tissue: PPARGC1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PPARGC1A


DatabasePathway IDPathway Des.
pidatf2_pathwayATF-2 transcription factor network
pidhdac_classiii_pathwaySignaling events mediated by HDAC Class III
pidmtor_4pathwaymTOR signaling pathway
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
pharmgkbPA165948566Metformin Pathway, Pharmacodynamic
wikipathwaysWP1541Energy Metabolism
wikipathwaysWP2011SREBF and miR33 in cholesterol and lipid homeostasis
wikipathwaysWP236Adipogenesis
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2879Farnesoid X Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2887Lipid storage and perilipins in skeletal muscle
wikipathwaysWP2895Differentiation of white and brown adipocyte
wikipathwaysWP3407FTO Obesity Variant Mechanism
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathwaysWP391Mitochondrial Gene Expression
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4010Liver steatosis AOP
wikipathwaysWP4191Caloric restriction and aging
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP98Prostaglandin Synthesis and Regulation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2151201Transcriptional activation of mitochondrial biogenesis
reactomeR-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylation
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
biocartapgc1apathwayregulation of pgc-1a
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD84Lovastatin acid1
iGMDRD307Manumycin A7
iGMDRD532Olaparib3
iGMDRD79Gemcitabine4
iGMDRD314Tanespimycin3
iGMDRD211(1S,3R)-RSL31
iGMDRD901ELCPK2
iGMDRD177Teniposide4
iGMDRD123Isoevodiamine1
iGMDRD154NSC237661
iGMDRD137Indisulam3
iGMDRD202Curcumin1
iGMDRD158NSC1415407
iGMDRD289Parthenolide1
iGMDRD481Dactolisib1
iGMDRD871BRD63684
iGMDRD414MST-3123
iGMDRD872BRD71372
iGMDRD882CIL412
iGMDRD505Pevonedistat5
iGMDRD147Prima-12
iGMDRD889Compound 7d-cis6
iGMDRD1008SR-II-138A1
iGMDRD772BRD47703
iGMDRD425ERASTIN2
iGMDRD144NSC953974
iGMDRD781Sirolimus4
iGMDRD446LY 21832401
iGMDRD152179324-69-74
iGMDRD61Kinetin riboside3
iGMDRD394BX-7951
iGMDRD280CYTOCHALASIN B3
iGMDRD466Chaetocin5
iGMDRD138PX 122
iGMDRD255SB2250021
iGMDRD782DC-45-A23
iGMDRD885Compound 1101
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD187BRD98762
iGMDRD870BRD636102
iGMDRD188Piperlongumine1
iGMDRD887Compound 23 citrate1
iGMDRD399Selumetinib2
iGMDRD562Navitoclax3
iGMDRD780PP-305
iGMDRD690PRIMA-1MET6
iGMDRD268Cerulenin1
iGMDRD23Gossypol3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PPARGC1A

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