PPARGC1A
Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604517 Ensembl IDEnsembl:ENSG00000109819 HGNC IDHGNC:HGNC:9237 PHARMGKB IDPA33558 Map Location4p15.2 | |||||
GO terms in PPARGC1A
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003712 | transcription coregulator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PPARGC1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPARGC1A
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPARGC1A
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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