PPARGC1A
Summary: The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PPARG coactivator 1 alpha | MIM:604517 | Ensembl:ENSG00000109819 | HGNC:HGNC:9237 | PA33558 | 4p15.2 |
GO terms in PPARGC1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | TAS | GO:0003712 | transcription coregulator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | TAS | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0016922 | nuclear receptor binding |
| MF | IEA | GO:0030331 | estrogen receptor binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | IDA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | ISS | GO:0031490 | chromatin DNA binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0042975 | peroxisome proliferator activated receptor binding |
| MF | IEA | GO:0043014 | alpha-tubulin binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | NAS | GO:0050681 | androgen receptor binding |
| MF | IEA | GO:1990841 | promoter-specific chromatin binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005665 | DNA-directed RNA polymerase II, core complex |
| CC | IEA | GO:0005719 | nuclear euchromatin |
| CC | IEA | GO:0016605 | PML body |
| CC | IEA | GO:0022626 | cytosolic ribosome |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0097440 | apical dendrite |
| CC | IEA | GO:1990843 | subsarcolemmal mitochondrion |
| CC | IEA | GO:1990844 | interfibrillar mitochondrion |
| BP | IEA | GO:0000302 | response to reactive oxygen species |
| BP | IEA | GO:0000422 | autophagy of mitochondrion |
| BP | TAS | GO:0001659 | temperature homeostasis |
| BP | NAS | GO:0001678 | cellular glucose homeostasis |
| BP | IEA | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IEA | GO:0002021 | response to dietary excess |
| BP | IEA | GO:0002931 | response to ischemia |
| BP | IEA | GO:0006012 | galactose metabolic process |
| BP | NAS | GO:0006094 | gluconeogenesis |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006397 | mRNA processing |
| BP | NAS | GO:0007005 | mitochondrion organization |
| BP | TAS | GO:0007005 | mitochondrion organization |
| BP | IEA | GO:0007568 | aging |
| BP | TAS | GO:0007586 | digestion |
| BP | TAS | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0008209 | androgen metabolic process |
| BP | TAS | GO:0008380 | RNA splicing |
| BP | IEA | GO:0009409 | response to cold |
| BP | IMP | GO:0010822 | positive regulation of mitochondrion organization |
| BP | ISS | GO:0010822 | positive regulation of mitochondrion organization |
| BP | IEA | GO:0014732 | skeletal muscle atrophy |
| BP | ISS | GO:0014850 | response to muscle activity |
| BP | IEA | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation |
| BP | IEA | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | NAS | GO:0019395 | fatty acid oxidation |
| BP | IEA | GO:0021549 | cerebellum development |
| BP | ISS | GO:0022904 | respiratory electron transport chain |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | IEA | GO:0030900 | forebrain development |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | ISS | GO:0034599 | cellular response to oxidative stress |
| BP | TAS | GO:0035066 | positive regulation of histone acetylation |
| BP | IEA | GO:0035865 | cellular response to potassium ion |
| BP | NAS | GO:0042594 | response to starvation |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | IEA | GO:0043201 | response to leucine |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | TAS | GO:0045333 | cellular respiration |
| BP | TAS | GO:0045722 | positive regulation of gluconeogenesis |
| BP | IEA | GO:0045820 | negative regulation of glycolytic process |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0046321 | positive regulation of fatty acid oxidation |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | TAS | GO:0050821 | protein stabilization |
| BP | TAS | GO:0050873 | brown fat cell differentiation |
| BP | IBA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0051552 | flavone metabolic process |
| BP | IEA | GO:0060612 | adipose tissue development |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IEA | GO:0071250 | cellular response to nitrite |
| BP | IEA | GO:0071313 | cellular response to caffeine |
| BP | IEA | GO:0071332 | cellular response to fructose stimulus |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071354 | cellular response to interleukin-6 |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| BP | IEA | GO:0071392 | cellular response to estradiol stimulus |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IEA | GO:0071871 | response to epinephrine |
| BP | IEA | GO:0071873 | response to norepinephrine |
| BP | IEA | GO:0090258 | negative regulation of mitochondrial fission |
| BP | ISS | GO:0097009 | energy homeostasis |
| BP | IEA | GO:0097067 | cellular response to thyroid hormone stimulus |
| BP | IGI | GO:1901215 | negative regulation of neuron death |
| BP | IEA | GO:1901558 | response to metformin |
| BP | IEA | GO:1901857 | positive regulation of cellular respiration |
| BP | IEA | GO:1901860 | positive regulation of mitochondrial DNA metabolic process |
| BP | IEA | GO:1901863 | positive regulation of muscle tissue development |
| BP | IEA | GO:1904635 | positive regulation of glomerular visceral epithelial cell apoptotic process |
| BP | IEA | GO:1904637 | cellular response to ionomycin |
| BP | IEA | GO:1904639 | cellular response to resveratrol |
| BP | IEA | GO:1904640 | response to methionine |
| BP | IEA | GO:1990845 | adaptive thermogenesis |
| BP | IEA | GO:2000184 | positive regulation of progesterone biosynthetic process |
| BP | IEA | GO:2000272 | negative regulation of signaling receptor activity |
| BP | IEA | GO:2000310 | regulation of NMDA receptor activity |
| BP | ISS | GO:2001171 | positive regulation of ATP biosynthetic process |
Gene expression in normal tissue: PPARGC1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPARGC1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| pharmgkb | PA165948566 | Metformin Pathway, Pharmacodynamic |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2879 | Farnesoid X Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2887 | Lipid storage and perilipins in skeletal muscle |
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3407 | FTO Obesity Variant Mechanism |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP391 | Mitochondrial Gene Expression |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4191 | Caloric restriction and aging |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2151209 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| reactome | R-HSA-8939902 | Regulation of RUNX2 expression and activity |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD307 | Manumycin A | 7 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 7 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 5 |
| iGMDRD690 | PRIMA-1MET | 6 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD23 | Gossypol | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPARGC1A
CLASSFICATION
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